New Dihydrobenzofuran Derivative, Awajanoran, from Marine-derived Acremonium sp. AWA16-1

Awajanoran ( 1 ), a new dihydrobenzofuran derivative, was isolated from an agar-culture of Acremonium sp. AWA16-1, which had been isolated from sea mud collected at Awajishima Island in Japan. The structure of 1 was elucidated on the basis of a spectroscopic analysis. This compound inhibited the gro...

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Veröffentlicht in:	Journal of antibiotics 2006-07, Vol.59 (7), p.428-431
Hauptverfasser:	Jang, Jae-Hyuk, Kanoh, Kaneo, Adachi, Kyoko, Shizuri, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acremonium Acremonium - metabolism Adenocarcinoma - drug therapy Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Bacteriology Benzofurans - chemistry Benzofurans - metabolism Benzofurans - pharmacology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Humans Inhibitory Concentration 50 Life Sciences Lung Neoplasms - drug therapy Marine Medicinal Chemistry Microbiology Molecular Structure Organic Chemistry Phenols - chemistry Phenols - metabolism Phenols - pharmacology
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Zusammenfassung:	Awajanoran ( 1 ), a new dihydrobenzofuran derivative, was isolated from an agar-culture of Acremonium sp. AWA16-1, which had been isolated from sea mud collected at Awajishima Island in Japan. The structure of 1 was elucidated on the basis of a spectroscopic analysis. This compound inhibited the growth of A549 cells, the human lung adenocarcinoma cell line, with an IC 50 value of 17 μg/ml, and also showed antimicrobial activity.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2006.60