Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

When T cells from a bone marrow donor begin to attack the host within 3 months after hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease mainly affects the skin, liver, and gastrointestinal tract and is treated with immunosuppressive drugs.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2017-11, Vol.377 (22), p.2167-2179
Hauptverfasser:	Zeiser, Robert, Blazar, Bruce R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adenosine Animals Antigens Blood diseases Bone marrow Cyclin-dependent kinases Cytokines Dendritic cells Disease Models, Animal Gastrointestinal tract Glucocorticoids - therapeutic use Graft versus host disease Graft vs Host Disease - immunology Graft vs Host Disease - pathology Graft vs Host Disease - prevention & control Graft vs Host Disease - therapy Graft-versus-host reaction Growth factors Hematopoietic Stem Cell Transplantation - adverse effects Humans Immunology Immunosuppression Immunosuppressive agents Kinases Leukemia Lymphatic system Lymphocytes Lymphocytes T Mice Neutrophils Proteins Risk factors Stem cell transplantation T-Lymphocytes - physiology Transplantation Transplantation Immunology Transplantation, Homologous Transplants & implants Tumor necrosis factor-TNF
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Beschreibung
Zusammenfassung:	When T cells from a bone marrow donor begin to attack the host within 3 months after hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease mainly affects the skin, liver, and gastrointestinal tract and is treated with immunosuppressive drugs.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMra1609337