Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed reaction under controlled conditions, three no...

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Veröffentlicht in:	Organic & biomolecular chemistry 2017, Vol.15 (47), p.10073-10081
Hauptverfasser:	Shiri, Morteza, Ranjbar, Maryam, Yasaei, Zahra, Zamanian, Fatemeh, Notash, Behrouz
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Cascade chemical reactions Controlled conditions Palladium Quinoline
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Zusammenfassung:	A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C-C, C-N, and C-O bonds in a one-pot procedure.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c7ob02043k