Total Synthesis of (+)-Medicarpin
(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as a...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2017-12, Vol.80 (12), p.3284-3288 |
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| Sprache: | eng |
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| container_end_page | 3288 |
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| container_issue | 12 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 80 |
| creator | Yang, Xiaoming Zhao, Yu Hsieh, Min-Tsang Xin, Guang Wu, Rong-Tsun Hsu, Pei-Lun Horng, Lin-Yea Sung, Hui-Ching Cheng, Chien-Hsin Lee, Kuo-Hsiung |
| description | (+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as an erythropoietin inducer for erythropoietin-deficient diseases. |
| doi_str_mv | 10.1021/acs.jnatprod.7b00741 |
| format | Article |
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Nat. Prod</addtitle><description>(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. 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| source | ACS Publications |
| title | Total Synthesis of (+)-Medicarpin |
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