Total Synthesis of (+)-Medicarpin

Total Synthesis of (+)-Medicarpin

(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2017-12, Vol.80 (12), p.3284-3288
Hauptverfasser: Yang, Xiaoming, Zhao, Yu, Hsieh, Min-Tsang, Xin, Guang, Wu, Rong-Tsun, Hsu, Pei-Lun, Horng, Lin-Yea, Sung, Hui-Ching, Cheng, Chien-Hsin, Lee, Kuo-Hsiung
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as an erythropoietin inducer for erythropoietin-deficient diseases.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.7b00741