The suppressive effect of beta-glucan on the production of tumor necrosis factor-alpha in BV2 microglial cells

Beta-Glucan was recently shown to have the ability to enhance and stimulate the immune system in humans, but little is known about its the anti-inflammatory effects. We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory media...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007, Vol.71 (5), p.1360-1364
Hauptverfasser:	Jung, K.H.(Kyung Hee Univ., Seoul (Korea R.)), Kim, M.J, Ha, E, Kim, H.K, Kim, Y.O, Kang, S.A, Chung, J.H, Yim, S.V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ANTI-INFLAMMATOIRE Anti-Inflammatory Agents - pharmacology ANTIINFLAMMATORY AGENTS ANTINFLAMATORIOS beta-Glucans - chemistry beta-Glucans - pharmacology Biological and medical sciences Cell Survival - drug effects CELLS Cells, Cultured CELLULE CELULAS CITOQUINAS CYTOKINE CYTOKINES Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Formazans - metabolism Fundamental and applied biological sciences. Psychology GLUCANE GLUCANOS GLUCANS Glucosides - chemistry LIPOPOLISACARIDOS LIPOPOLYSACCHARIDE lipopolysaccharide (LPS) LIPOPOLYSACCHARIDES Lipopolysaccharides - pharmacology Mice Microglia - drug effects Microglia - metabolism Molecular Weight NEOPLASMAS NEOPLASME NEOPLASMS NF-kappa B - antagonists & inhibitors nuclear factor kappa B (NF-κB) RNA, Messenger - metabolism Tetrazolium Salts - metabolism Time Factors tumor necrosis factor-alpha (TNF-α) Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics β-glucan
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Zusammenfassung:	Beta-Glucan was recently shown to have the ability to enhance and stimulate the immune system in humans, but little is known about its the anti-inflammatory effects. We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Beta-Glucan decreased the production and expression of TNF-alpha. In addition, it blocked LPS-stimulated activation of nuclear factor kappa B (NF-kappaB). Hence beta-glucan might suppress LPS-stimulated TNF-alpha production by inhibiting NF-kappaB in BV2 microglial cells.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.60608