An intermediate sFlt-1/PlGF ratio indicates an increased risk for adverse pregnancy outcome

•Chronic maternal diseases, fetal diseases or twin pregnancies were frequent.•The risk for prematurity or growth restriction is increased.•Preeclampsia develops rather later in pregnancy and mostly with mild forms.•The risk for preterm birth seems to be independent from preeclampsia.•Close clinical controls are recommended when sFlt-1/PlGF ratio is intermediate. Objective: The sFlt-1/PlGF ratio is a valid marker in diagnosing or excluding preeclampsia. The currently used cut offs frame an intermediate zone of 33–85 (