Over-expression of cyclooxygenase-2 in increased reticulated platelets leads to aspirin resistance after elective off-pump coronary artery bypass surgery

Aspirin resistance (AR) has been reported to present after coronary artery bypass graft causing saphenous vein graft failure. We aimed to investigate the factors that affect the anti-platelet effect of aspirin after off-pump coronary artery bypass surgery (OPCAB). Thirty OPCAB candidates were succes...

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Veröffentlicht in:	Thrombosis research 2017-12, Vol.160, p.114-118
Hauptverfasser:	Gong, Xiaoxuan, Wang, Xuezhong, Xu, Zhuowen, Zhu, Tiantian, Zhang, Qiu, Zhang, Jinying, Wang, Xiaowei, Li, Chunjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aspirin - pharmacology Aspirin - therapeutic use Aspirin resistance (AR) Blood Platelets - drug effects Coronary Artery Bypass, Off-Pump - methods Coronary artery disease (CAD) Coronary Artery Disease - drug therapy Cyclooxygenase (COX) Cyclooxygenase 2 - metabolism Drug Resistance - physiology Female Humans Male Middle Aged Off-pump coronary artery bypass (OPCAB)
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Zusammenfassung:	Aspirin resistance (AR) has been reported to present after coronary artery bypass graft causing saphenous vein graft failure. We aimed to investigate the factors that affect the anti-platelet effect of aspirin after off-pump coronary artery bypass surgery (OPCAB). Thirty OPCAB candidates were successively recruited. Platelet count, platelet aggregation, reticulated platelet (RP), platelets' cyclooxygenase (COX)-1 and COX-2 expressions were determined during the peri-operative period. Besides, 10 healthy volunteers were enrolled to determine the onset of the anti-platelet effect of aspirin as comparison. The arachidonic acid-induced platelet aggregation (PLAA) decreased to
ISSN:	0049-3848 1879-2472
DOI:	10.1016/j.thromres.2017.11.003