FAK, Src and p-Paxillin expression is decreased in liver metastasis of colorectal carcinoma patients

FAK, Src and p-Paxillin expression is decreased in liver metastasis of colorectal carcinoma patients

The FAK/Src/Paxillin (PXN) axis has been implicated in malignant transformation, tumor growth, progression and metastasis. The present study aimed to assess FAK/Src/PXN protein expression in both primary and liver metastatic sites of colorectal adenocarcinoma (CRC). FAK, Src and p-PXN expression was...

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Veröffentlicht in:Journal of B.U. ON. 2017-09, Vol.22 (5), p.1097-1106
Hauptverfasser: Mantonakis, Eleftherios, Giaginis, Constantinos, Pikoulis, Emmanouel, Felekouras, Evangelos, Patsouris, Efstratios, Liakakos, Theodoros, Papalampros, Efstathios, Theocharis, Stamatios
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Sprache:eng
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Zusammenfassung:The FAK/Src/Paxillin (PXN) axis has been implicated in malignant transformation, tumor growth, progression and metastasis. The present study aimed to assess FAK/Src/PXN protein expression in both primary and liver metastatic sites of colorectal adenocarcinoma (CRC). FAK, Src and p-PXN expression was assessed immunohistochemically on 32 primary CRCs and their corresponding liver metastases, being also analyzed in relation with clinicopathological characteristics and patient survival. FAK, Src and p-PXN expression was significantly decreased in liver metastasis compared to matched paired primary CRCs (p
ISSN:1107-0625