Preparation of microcapsules for skin allergy testing by the solvent evaporation process

Polyurethanes and polyvinyl alcohol modified by stearyl isocyanate are used as a matrix for microparticles made by a solvent evaporation process to encapsulate allergenic molecules, with petrolatum used as a neutral vehicle. The encapsulation yields, depending on the agent to be encapsulated, vary f...

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Veröffentlicht in:	Journal of microencapsulation 2000, Vol.17 (1), p.111-116
Hauptverfasser:	BROSSE, C, SOUTIF, J.-C, BROSSE, J.-C
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergen Microparticle Polyurethane Microencapsulation Polymeric Matrix Allergens - administration & dosage Allergens - immunology Benzocaine - administration & dosage Benzocaine - immunology Benzocaine - metabolism Biological and medical sciences Capsules - chemical synthesis Capsules - chemistry Capsules - metabolism Chemistry, Pharmaceutical Cyanates Dermatitis, Contact - diagnosis Dermatitis, Contact - immunology Drug Compounding - methods Drug Stability Drug Storage General pharmacology Histamine and antagonists. Allergy Humans Medical sciences Methanol - metabolism Microscopy, Electron, Scanning Petrolatum Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyurethanes - chemistry Polyvinyl Alcohol - analogs & derivatives Polyvinyl Alcohol - chemistry Skin Tests Solubility Solutions Solvents Spectrophotometry, Ultraviolet Water - metabolism
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Beschreibung
Zusammenfassung:	Polyurethanes and polyvinyl alcohol modified by stearyl isocyanate are used as a matrix for microparticles made by a solvent evaporation process to encapsulate allergenic molecules, with petrolatum used as a neutral vehicle. The encapsulation yields, depending on the agent to be encapsulated, vary from 22 to 45%.
ISSN:	0265-2048 1464-5246
DOI:	10.1080/026520400288599