Prognostic Value of Bcl 10 Rearrangement in Diffuse Large B-cell Lymphoma

The role of bcl 10, a recently cloned apoptosis-associated gene, in diffuse large B-cell lymphoma (DLBL) is unknown. Here we determined the role of bcl 10 gene rearrangement on prognosis. Bcl 10 rearrangement was examined by Southern blot. Bcl 10 rearrangement was detected in 20 of 137 (14.6%) sampl...

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Veröffentlicht in:	Leukemia & lymphoma 2002-01, Vol.43 (4), p.823-826
Hauptverfasser:	Kawasaki, C., Ohshima, K., Muta, H., Muta, K., Deyev, V., Podack, E.R., Kikuchi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Bcl 10 Caspase Recruitment Domain Child Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 14 Diffuse Large B-cell Lymphoma Gene Rearrangement Humans Lymphoma, B-Cell - genetics Lymphoma, B-Cell - mortality Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Middle Aged Mucosa-associated Lymphoid Tissue Prognosis Proto-Oncogenes Survival Rate Translocation, Genetic
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Zusammenfassung:	The role of bcl 10, a recently cloned apoptosis-associated gene, in diffuse large B-cell lymphoma (DLBL) is unknown. Here we determined the role of bcl 10 gene rearrangement on prognosis. Bcl 10 rearrangement was examined by Southern blot. Bcl 10 rearrangement was detected in 20 of 137 (14.6%) samples of DLBL. The frequency of bcl 10 rearrangement was higher in extranodal (eight of 38 cases, 21%) than in nodal (12 of 99, 12%) DLBL. The survival rate in patients with bcl 10 rearrangement tended to be better than in those with germ-line bcl 10, albeit statistically insignificant probably due to the small population sample. The superior prognosis in patients with bcl 10 rearrangement might be due to bcl 10-induced enhanced apoptosis.
ISSN:	1042-8194 1029-2403
DOI:	10.1080/10428190290016953