Hypercalcemia due to all trans retinoic acid in the treatment of acute promyelocytic leukemia potentiated by voriconazole

All-trans-retinoic acid (ATRA) is a new and effective treatment of acute promyelocytic leukemia. It has many side-effects, including the retinoic acid syndrome and Sweet's syndrome. There have been only nine cases of hypercalcemia associated with ATRA described in the literature. We discuss a c...

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Veröffentlicht in:	Leukemia & lymphoma 2005-12, Vol.46 (12), p.1829-1831
Hauptverfasser:	Bennett, Matthew T., Sirrs, Sandra, Yeung, Janice K., Smith, Clayton A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antifungal Agents - adverse effects Antineoplastic Agents - adverse effects Female Humans Hypercalcemia - chemically induced Leukemia, Promyelocytic, Acute - drug therapy Pyrimidines - adverse effects Treatment Outcome Tretinoin - adverse effects Triazoles - adverse effects Voriconazole
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Zusammenfassung:	All-trans-retinoic acid (ATRA) is a new and effective treatment of acute promyelocytic leukemia. It has many side-effects, including the retinoic acid syndrome and Sweet's syndrome. There have been only nine cases of hypercalcemia associated with ATRA described in the literature. We discuss a case of hypercalcemia, which we believe was due to inhibition of cytochrome P450 function by voriconizole when used concomitantly with ATRA.
ISSN:	1042-8194 1029-2403
DOI:	10.1080/10428190500235298