Pentosidine concentration is associated with degenerative lumbar scoliosis in older women: preliminary results

Purpose Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. The objective of the study was to investigate the prevalence of sarcopenia in degenerative lumbar scoliosis (DLS), and the relationship between biochemical markers including major AGEs, pentosidine, and DLS in older women. Methods Our study participants were 20 elderly women with idiopathic DLS (mean age 76.4 years, range 56–88). Nineteen age- and sex-matched volunteers (mean age 74.0 years, range 62–86) served as controls. Spinal and femoral BMD of all participants was measured using dual-energy X-ray absorptiometry. We used a bioelectrical impedance analyzer to analyze body composition, including appendicular skeletal muscle mass index [SMI; appendicular lean mass (kg)/(height (m)] 2 . SMI