Evaluation of the Roche® Elecsys and the Diasorin® Liaison S100 kits in the management of mild head injury in the emergency room
The aim of this single-center prospective study is to compare two commercially available S100ß kits (the Roche® Elecsys and the Diasorin® Liaison S100 kits) in terms of analytical and clinical performances in a population admitted in the emergency room for mild traumatic brain injury (mTBI). 110 pat...
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| Veröffentlicht in: | Clinical biochemistry 2018-02, Vol.52, p.123-130 |
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| creator | Delefortrie, Quentin Lejeune, François Kerzmann, Benjamin Levy, Raphaël Adam, Jean-François Sottiaux, Thierry Grimmelprez, Alexandre Vankerkhoven, Patrick Hachimi-Idrissi, Said |
| description | The aim of this single-center prospective study is to compare two commercially available S100ß kits (the Roche® Elecsys and the Diasorin® Liaison S100 kits) in terms of analytical and clinical performances in a population admitted in the emergency room for mild traumatic brain injury (mTBI).
110 patients were enrolled from September 2014 to May 2015. Blood sample draws were performed within 3h after head trauma and the study population was split into pediatric and adult subpopulations (>18years of age).
Although both kits correlated well, we observed a significant difference in terms of S100ß levels (P value |
| doi_str_mv | 10.1016/j.clinbiochem.2017.11.004 |
| format | Article |
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110 patients were enrolled from September 2014 to May 2015. Blood sample draws were performed within 3h after head trauma and the study population was split into pediatric and adult subpopulations (>18years of age).
Although both kits correlated well, we observed a significant difference in terms of S100ß levels (P value<0.05) in both subpopulations.
In the pediatric subpopulation, both kits showed elevated S100ß levels for the only patient (3.5%) who displayed abnormal findings on a CT-scan. However, we observed a poor agreement between both kits (Cohen's kappa=0.345, P value=0.077).
In the adult subpopulation, a total of 10 patients (12.2%) had abnormal head computed tomography scans. Using the Roche® (cut off=0.1μg/L) and the Diasorin® (cut off=0.15μg/L) S100ß kits, brain injuries were detected with a sensitivity of 100% (95% CI: 65–100%) and 100% (95% CI: 63–100%) and a specificity of 15.28% (95% CI: 7.9–25.7%) and 24.64% (95% CI: 15–36.5) respectively. Finally, a moderate agreement was concluded between both kits (Cohen's kappa=0.569, P value=0.001).
Although a good correlation could be found between both kits, emergency physicians should be aware of discrepancies observed between both methods, making those immunoassays not interchangeable. Furthermore, more studies are still needed to validate cut off used according to technique and to age, especially in the population below the age of 2years.
•Management of mTBI in the emergency room•Roche® and Diasorin® S100ß kits evaluated in children and adults•In a cohort of 28 infants, both kits detected the only abnormal CT-scan•Within the pediatric population, poor agreement between both kits•All adults with abnormal CT-scans had elevated S100ß protein values</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2017.11.004</identifier><identifier>PMID: 29122642</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><ispartof>Clinical biochemistry, 2018-02, Vol.52, p.123-130</ispartof><rights>2017 The Canadian Society of Clinical Chemists</rights><rights>Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-4a1c6d62111408bea2547adad6ee69f0a8b7233a83d32caf77642ae174b27e353</citedby><cites>FETCH-LOGICAL-c377t-4a1c6d62111408bea2547adad6ee69f0a8b7233a83d32caf77642ae174b27e353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912017307609$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29122642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delefortrie, Quentin</creatorcontrib><creatorcontrib>Lejeune, François</creatorcontrib><creatorcontrib>Kerzmann, Benjamin</creatorcontrib><creatorcontrib>Levy, Raphaël</creatorcontrib><creatorcontrib>Adam, Jean-François</creatorcontrib><creatorcontrib>Sottiaux, Thierry</creatorcontrib><creatorcontrib>Grimmelprez, Alexandre</creatorcontrib><creatorcontrib>Vankerkhoven, Patrick</creatorcontrib><creatorcontrib>Hachimi-Idrissi, Said</creatorcontrib><title>Evaluation of the Roche® Elecsys and the Diasorin® Liaison S100 kits in the management of mild head injury in the emergency room</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>The aim of this single-center prospective study is to compare two commercially available S100ß kits (the Roche® Elecsys and the Diasorin® Liaison S100 kits) in terms of analytical and clinical performances in a population admitted in the emergency room for mild traumatic brain injury (mTBI).
110 patients were enrolled from September 2014 to May 2015. Blood sample draws were performed within 3h after head trauma and the study population was split into pediatric and adult subpopulations (>18years of age).
Although both kits correlated well, we observed a significant difference in terms of S100ß levels (P value<0.05) in both subpopulations.
In the pediatric subpopulation, both kits showed elevated S100ß levels for the only patient (3.5%) who displayed abnormal findings on a CT-scan. However, we observed a poor agreement between both kits (Cohen's kappa=0.345, P value=0.077).
In the adult subpopulation, a total of 10 patients (12.2%) had abnormal head computed tomography scans. Using the Roche® (cut off=0.1μg/L) and the Diasorin® (cut off=0.15μg/L) S100ß kits, brain injuries were detected with a sensitivity of 100% (95% CI: 65–100%) and 100% (95% CI: 63–100%) and a specificity of 15.28% (95% CI: 7.9–25.7%) and 24.64% (95% CI: 15–36.5) respectively. Finally, a moderate agreement was concluded between both kits (Cohen's kappa=0.569, P value=0.001).
Although a good correlation could be found between both kits, emergency physicians should be aware of discrepancies observed between both methods, making those immunoassays not interchangeable. Furthermore, more studies are still needed to validate cut off used according to technique and to age, especially in the population below the age of 2years.
•Management of mTBI in the emergency room•Roche® and Diasorin® S100ß kits evaluated in children and adults•In a cohort of 28 infants, both kits detected the only abnormal CT-scan•Within the pediatric population, poor agreement between both kits•All adults with abnormal CT-scans had elevated S100ß protein values</description><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNkc9u1DAQxi0EotvCKyBz45LgP6mdHNGyQKWVkPhztib2pOslsYudVNprH4iH4MnwdlvEkZPlmd_3jWY-Ql5zVnPG1dt9bUcfeh_tDqdaMK5rzmvGmidkxVstK9FJ-ZSsGGNd1XHBzsh5zvvyFU2rnpMzUYpCNWJF7ja3MC4w-xhoHOi8Q_rlaPv7F92MaPMhUwjuvv7eQ47Jh9LaevC5KL5yxugPP2fqwz0zQYBrnDDMR7fJj47uEFxp75d0eKQKkK4x2ANNMU4vyLMBxowvH94L8v3D5tv6U7X9_PFq_W5bWan1XDXArXJKcM4b1vYI4rLR4MApRNUNDNpeCymhlU4KC4PWZUFArpteaJSX8oK8OfnepPhzwTybyWeL4wgB45IN75QUqpNaFrQ7oTbFnBMO5ib5CdLBcGaOEZi9-ScCc4zAcG5KBEX76mHM0k_o_iofb16A9QnAsuytx2Sy9eUa6HxCOxsX_X-M-QOnZJ9Y</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Delefortrie, Quentin</creator><creator>Lejeune, François</creator><creator>Kerzmann, Benjamin</creator><creator>Levy, Raphaël</creator><creator>Adam, Jean-François</creator><creator>Sottiaux, Thierry</creator><creator>Grimmelprez, Alexandre</creator><creator>Vankerkhoven, Patrick</creator><creator>Hachimi-Idrissi, Said</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201802</creationdate><title>Evaluation of the Roche® Elecsys and the Diasorin® Liaison S100 kits in the management of mild head injury in the emergency room</title><author>Delefortrie, Quentin ; Lejeune, François ; Kerzmann, Benjamin ; Levy, Raphaël ; Adam, Jean-François ; Sottiaux, Thierry ; Grimmelprez, Alexandre ; Vankerkhoven, Patrick ; Hachimi-Idrissi, Said</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-4a1c6d62111408bea2547adad6ee69f0a8b7233a83d32caf77642ae174b27e353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delefortrie, Quentin</creatorcontrib><creatorcontrib>Lejeune, François</creatorcontrib><creatorcontrib>Kerzmann, Benjamin</creatorcontrib><creatorcontrib>Levy, Raphaël</creatorcontrib><creatorcontrib>Adam, Jean-François</creatorcontrib><creatorcontrib>Sottiaux, Thierry</creatorcontrib><creatorcontrib>Grimmelprez, Alexandre</creatorcontrib><creatorcontrib>Vankerkhoven, Patrick</creatorcontrib><creatorcontrib>Hachimi-Idrissi, Said</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delefortrie, Quentin</au><au>Lejeune, François</au><au>Kerzmann, Benjamin</au><au>Levy, Raphaël</au><au>Adam, Jean-François</au><au>Sottiaux, Thierry</au><au>Grimmelprez, Alexandre</au><au>Vankerkhoven, Patrick</au><au>Hachimi-Idrissi, Said</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Roche® Elecsys and the Diasorin® Liaison S100 kits in the management of mild head injury in the emergency room</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2018-02</date><risdate>2018</risdate><volume>52</volume><spage>123</spage><epage>130</epage><pages>123-130</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>The aim of this single-center prospective study is to compare two commercially available S100ß kits (the Roche® Elecsys and the Diasorin® Liaison S100 kits) in terms of analytical and clinical performances in a population admitted in the emergency room for mild traumatic brain injury (mTBI).
110 patients were enrolled from September 2014 to May 2015. Blood sample draws were performed within 3h after head trauma and the study population was split into pediatric and adult subpopulations (>18years of age).
Although both kits correlated well, we observed a significant difference in terms of S100ß levels (P value<0.05) in both subpopulations.
In the pediatric subpopulation, both kits showed elevated S100ß levels for the only patient (3.5%) who displayed abnormal findings on a CT-scan. However, we observed a poor agreement between both kits (Cohen's kappa=0.345, P value=0.077).
In the adult subpopulation, a total of 10 patients (12.2%) had abnormal head computed tomography scans. Using the Roche® (cut off=0.1μg/L) and the Diasorin® (cut off=0.15μg/L) S100ß kits, brain injuries were detected with a sensitivity of 100% (95% CI: 65–100%) and 100% (95% CI: 63–100%) and a specificity of 15.28% (95% CI: 7.9–25.7%) and 24.64% (95% CI: 15–36.5) respectively. Finally, a moderate agreement was concluded between both kits (Cohen's kappa=0.569, P value=0.001).
Although a good correlation could be found between both kits, emergency physicians should be aware of discrepancies observed between both methods, making those immunoassays not interchangeable. Furthermore, more studies are still needed to validate cut off used according to technique and to age, especially in the population below the age of 2years.
•Management of mTBI in the emergency room•Roche® and Diasorin® S100ß kits evaluated in children and adults•In a cohort of 28 infants, both kits detected the only abnormal CT-scan•Within the pediatric population, poor agreement between both kits•All adults with abnormal CT-scans had elevated S100ß protein values</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29122642</pmid><doi>10.1016/j.clinbiochem.2017.11.004</doi><tpages>8</tpages></addata></record> |
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| title | Evaluation of the Roche® Elecsys and the Diasorin® Liaison S100 kits in the management of mild head injury in the emergency room |
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