Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov
Two novel anthraquinones, lupinacidins A ( 1) and B ( 2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells. Two novel anthraquinones, lupinacidins A ( 1) and B ( 2), have been...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (13), p.3702-3705 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Igarashi, Yasuhiro Trujillo, Martha E. Martínez-Molina, Eustoquio Yanase, Saeko Miyanaga, Satoshi Obata, Takamasa Sakurai, Hiroaki Saiki, Ikuo Fujita, Tsuyoshi Furumai, Tamotsu |
| description | Two novel anthraquinones, lupinacidins A (
1) and B (
2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells.
Two novel anthraquinones, lupinacidins A (
1) and B (
2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus
Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth. |
| doi_str_mv | 10.1016/j.bmcl.2007.04.039 |
| format | Article |
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1) and B (
2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells.
Two novel anthraquinones, lupinacidins A (
1) and B (
2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus
Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2007.04.039</identifier><identifier>PMID: 17475486</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Anthraquinones - chemical synthesis ; Anthraquinones - chemistry ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Antitumor ; Applied microbiology ; Biological and medical sciences ; Cell Line, Tumor ; Cell Proliferation ; Chemistry, Pharmaceutical - methods ; Chemotherapic agents ; Colonic Neoplasms - drug therapy ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Fundamental and applied biological sciences. Psychology ; Inhibitory Concentration 50 ; Invasion ; Lupinacidin ; Magnetic Resonance Spectroscopy ; Mice ; Microbiology ; Micromonospora ; Models, Chemical ; Molecular Conformation</subject><ispartof>Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (13), p.3702-3705</ispartof><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-65017d682b43b09166b314794e4638217edfce31fa0c7a84f360d16fe404e4d53</citedby><cites>FETCH-LOGICAL-c481t-65017d682b43b09166b314794e4638217edfce31fa0c7a84f360d16fe404e4d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X07004593$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18859569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17475486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Igarashi, Yasuhiro</creatorcontrib><creatorcontrib>Trujillo, Martha E.</creatorcontrib><creatorcontrib>Martínez-Molina, Eustoquio</creatorcontrib><creatorcontrib>Yanase, Saeko</creatorcontrib><creatorcontrib>Miyanaga, Satoshi</creatorcontrib><creatorcontrib>Obata, Takamasa</creatorcontrib><creatorcontrib>Sakurai, Hiroaki</creatorcontrib><creatorcontrib>Saiki, Ikuo</creatorcontrib><creatorcontrib>Fujita, Tsuyoshi</creatorcontrib><creatorcontrib>Furumai, Tamotsu</creatorcontrib><title>Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Two novel anthraquinones, lupinacidins A (
1) and B (
2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells.
Two novel anthraquinones, lupinacidins A (
1) and B (
2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus
Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.</description><subject>Animals</subject><subject>Anthraquinones - chemical synthesis</subject><subject>Anthraquinones - chemistry</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitumor</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chemotherapic agents</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inhibitory Concentration 50</subject><subject>Invasion</subject><subject>Lupinacidin</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Micromonospora</subject><subject>Models, Chemical</subject><subject>Molecular Conformation</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVpabZpXqCH4kt7sztajWUbegmhSQspvbQlNyHLY6LFlhxJDuzbV2YXcutJMPrmn5mPsQ8cKg5cfjlU_Wymag_QVIAViO4V23GUWAqE-jXbQSehbDt8uGDvYjwAcATEt-yCN9jU2Mod-3vtkk3r7EOhXXoM-mm1zjuKxRj8nGsFucEvj8dkTaFNyp_z0VCi4qc1mfDOx8UHXUzrYp0t4lIVzj-_Z29GPUW6Or-X7M_tt98338v7X3c_bq7vS4MtT6WsgTeDbPc9ih46LmUvODYdEkrR7nlDw2hI8FGDaXSLo5AwcDlSvoNwqMUl-3zKXYJ_WikmNdtoaJq0I79GxTspoG03cH8C89IxBhrVEuysw1FxUJtNdVCbTbXZVIAq28xNH8_paz_T8NJy1peBT2dAR6OnMWhnbHzh8uSullvQ1xNH2cWzpaCiseQMDTaQSWrw9n97_ANyxpPa</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Igarashi, Yasuhiro</creator><creator>Trujillo, Martha E.</creator><creator>Martínez-Molina, Eustoquio</creator><creator>Yanase, Saeko</creator><creator>Miyanaga, Satoshi</creator><creator>Obata, Takamasa</creator><creator>Sakurai, Hiroaki</creator><creator>Saiki, Ikuo</creator><creator>Fujita, Tsuyoshi</creator><creator>Furumai, Tamotsu</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20070701</creationdate><title>Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov</title><author>Igarashi, Yasuhiro ; Trujillo, Martha E. ; Martínez-Molina, Eustoquio ; Yanase, Saeko ; Miyanaga, Satoshi ; Obata, Takamasa ; Sakurai, Hiroaki ; Saiki, Ikuo ; Fujita, Tsuyoshi ; Furumai, Tamotsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-65017d682b43b09166b314794e4638217edfce31fa0c7a84f360d16fe404e4d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anthraquinones - chemical synthesis</topic><topic>Anthraquinones - chemistry</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antitumor</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chemotherapic agents</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inhibitory Concentration 50</topic><topic>Invasion</topic><topic>Lupinacidin</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Micromonospora</topic><topic>Models, Chemical</topic><topic>Molecular Conformation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Igarashi, Yasuhiro</creatorcontrib><creatorcontrib>Trujillo, Martha E.</creatorcontrib><creatorcontrib>Martínez-Molina, Eustoquio</creatorcontrib><creatorcontrib>Yanase, Saeko</creatorcontrib><creatorcontrib>Miyanaga, Satoshi</creatorcontrib><creatorcontrib>Obata, Takamasa</creatorcontrib><creatorcontrib>Sakurai, Hiroaki</creatorcontrib><creatorcontrib>Saiki, Ikuo</creatorcontrib><creatorcontrib>Fujita, Tsuyoshi</creatorcontrib><creatorcontrib>Furumai, Tamotsu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Igarashi, Yasuhiro</au><au>Trujillo, Martha E.</au><au>Martínez-Molina, Eustoquio</au><au>Yanase, Saeko</au><au>Miyanaga, Satoshi</au><au>Obata, Takamasa</au><au>Sakurai, Hiroaki</au><au>Saiki, Ikuo</au><au>Fujita, Tsuyoshi</au><au>Furumai, Tamotsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>17</volume><issue>13</issue><spage>3702</spage><epage>3705</epage><pages>3702-3705</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Two novel anthraquinones, lupinacidins A (
1) and B (
2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells.
Two novel anthraquinones, lupinacidins A (
1) and B (
2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus
Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17475486</pmid><doi>10.1016/j.bmcl.2007.04.039</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anthraquinones - chemical synthesis Anthraquinones - chemistry Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumor Applied microbiology Biological and medical sciences Cell Line, Tumor Cell Proliferation Chemistry, Pharmaceutical - methods Chemotherapic agents Colonic Neoplasms - drug therapy Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Inhibitory Concentration 50 Invasion Lupinacidin Magnetic Resonance Spectroscopy Mice Microbiology Micromonospora Models, Chemical Molecular Conformation |
| title | Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov |
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