Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov

Two novel anthraquinones, lupinacidins A ( 1) and B ( 2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells. Two novel anthraquinones, lupinacidins A ( 1) and B ( 2), have been...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (13), p.3702-3705
Hauptverfasser:	Igarashi, Yasuhiro, Trujillo, Martha E., Martínez-Molina, Eustoquio, Yanase, Saeko, Miyanaga, Satoshi, Obata, Takamasa, Sakurai, Hiroaki, Saiki, Ikuo, Fujita, Tsuyoshi, Furumai, Tamotsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones - chemical synthesis Anthraquinones - chemistry Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumor Applied microbiology Biological and medical sciences Cell Line, Tumor Cell Proliferation Chemistry, Pharmaceutical - methods Chemotherapic agents Colonic Neoplasms - drug therapy Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Inhibitory Concentration 50 Invasion Lupinacidin Magnetic Resonance Spectroscopy Mice Microbiology Micromonospora Models, Chemical Molecular Conformation
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Zusammenfassung:	Two novel anthraquinones, lupinacidins A ( 1) and B ( 2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells. Two novel anthraquinones, lupinacidins A ( 1) and B ( 2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.04.039