The Metabolism of Fatty Alcohols in Lipid Nanoparticles by Alcohol Dehydrogenase

The Metabolism of Fatty Alcohols in Lipid Nanoparticles by Alcohol Dehydrogenase

ABSTRACT Fatty alcohols are commonly used in lipid-based drug delivery systems including parenteral emulsions and solid lipid nanoparticles (NPs). The purpose of these studies was to determine whether horse liver alcohol dehydrogenase (HLADH), a NAD-dependent enzyme, could metabolize the fatty alcoh...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Drug development and industrial pharmacy 2006-09, Vol.32 (8), p.973-980
Hauptverfasser: Dong, X., Mumper, R. J.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol Dehydrogenase - physiology
Animals
Biological and medical sciences
Cetyl alcohol
Chromatography, Gas
Enzyme
Fatty Alcohols - metabolism
Fluorescence
Gas chromatography
General pharmacology
Horses
Liver - enzymology
Medical sciences
NAD - metabolism
Nanoparticles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyethylene Glycols - pharmacology
Polyoxyethylene 20-stearyl ether (Brij 78)
Surfactant
β-nicotinamide adenine dinucleotide (NAD
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ABSTRACT Fatty alcohols are commonly used in lipid-based drug delivery systems including parenteral emulsions and solid lipid nanoparticles (NPs). The purpose of these studies was to determine whether horse liver alcohol dehydrogenase (HLADH), a NAD-dependent enzyme, could metabolize the fatty alcohols within the NPs and thus serve as a mechanism to degrade these NPs in the body. Solid nanoparticles (
ISSN:0363-9045
1520-5762
DOI:10.1080/03639040600640006