Perioperative Complications of Cesarean Delivery Myomectomy: A Meta-analysis

OBJECTIVE:To assess the association of myomectomy during cesarean delivery with intraoperative and perioperative maternal morbidity. DATA SOURCES:We searched MEDLINE (1966–2017), Scopus (2004–2017), ClinicalTrials.gov (2008–2017), EMBASE (1980–2017), and Cochrane Central Register of Controlled Trials CENTRAL (1999–2017) databases. METHODS OF STUDY SELECTION:We selected all observational studies that reported outcomes on patients undergoing myomectomy at the time of cesarean delivery. Statistical meta-analysis was performed with RevMan 5.3. RESULTS:Nineteen studies were included in our systematic review with a total number of 3,900 women. Among them, 2,301 women had myomectomy during cesarean delivery and 1,599 had cesarean delivery only. Women undergoing concomitant myomectomy had a mild decline in hemoglobin compared with those who had cesarean delivery only (mean difference 0.25 mg/dL, 95% CI 0.06–0.45). Myomectomy at the time of cesarean delivery is associated with longer surgical time compared with cesarean delivery alone (mean difference 13.87 minutes, 95% CI 4.78–22.95). Blood transfusion (odds ratio [OR] 1.41, 95% CI 0.96–2.07) and postoperative fever (OR 1.12, 95% CI 0.80–1.56) rates did not differ between the two groups (myomectomy compared with no myomectomy). A statistically, but not clinically, significant increase in postoperative hospitalization was evident in the myomectomy group (mean difference 0.35 days, 95% CI 0.25–0.46). CONCLUSION:This systematic review and meta-analysis of observational studies demonstrated an association with increased operative time and hemoglobin drop in patients who underwent cesarean myomectomy compared with cesarean delivery alone. No increased rate of major hemorrhage or need for transfusion was identified. Cesarean myomectomy may be considered in cases of isolated myomas, although randomized trials are needed.