A novel method for the synthesis of chiral epoxides from styrene derivatives using chiral acids in presence of Pseudomonas lipase G6 [PSL G6] and hydrogen peroxide

A novel method for the synthesis of chiral epoxides from styrene derivatives using chiral acids in presence of Pseudomonas lipase G6 [PSL G6] and hydrogen peroxide

Chiral epoxidation of styrene and its derivatives was carried out using series of chiral acids and urea hydrogen peroxide (UHP) or aqueous hydrogen peroxide (50%) in two phases under the catalytic influence of immobilized Pseudomonas lipase G6 [PSL G6] at 25–55 °C. A moderate to good yield and enant...

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Veröffentlicht in:Tetrahedron 2007-09, Vol.63 (36), p.8735-8741
Hauptverfasser: Sarma, Kuladip, Bhati, Nishi, Borthakur, Naleen, Goswami, Amrit
Format: Artikel
Sprache:eng
Schlagworte:
Chiral epoxides
Enantioselective epoxidation
Olefin
Peroxy acid
Pseudomonas
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Zusammenfassung:Chiral epoxidation of styrene and its derivatives was carried out using series of chiral acids and urea hydrogen peroxide (UHP) or aqueous hydrogen peroxide (50%) in two phases under the catalytic influence of immobilized Pseudomonas lipase G6 [PSL G6] at 25–55 °C. A moderate to good yield and enantioselectivities of chiral epoxides were obtained. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2007.06.046