Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity

Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity

Two closely structurally related coumarins, 4-hydroxy-8-isopropyl-5-methylcoumarin and 4-hydroxy-6-chloro-7-methylcoumarin were acylated at C-3 and further converted to the respective chalcones and two series of eighteen new compounds, which were evaluated for possible antiviral activity.

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Veröffentlicht in:Tetrahedron letters 2007-11, Vol.48 (48), p.8472-8474
Hauptverfasser: Trivedi, Jalpa C., Bariwal, Jitender B., Upadhyay, Kuldip D., Naliapara, Yogesh T., Joshi, Sudhir K., Pannecouque, Christophe C., De Clercq, Erik, Shah, Anamik K.
Format: Artikel
Sprache:eng
Schlagworte:
4-Hydroxycoumarins
Anti-HIV
Antiviral
Chalcones
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Zusammenfassung:Two closely structurally related coumarins, 4-hydroxy-8-isopropyl-5-methylcoumarin and 4-hydroxy-6-chloro-7-methylcoumarin were acylated at C-3 and further converted to the respective chalcones and two series of eighteen new compounds, which were evaluated for possible antiviral activity.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.09.175