Treatment with the MAPK kinase inhibitor U0126 during the first two hours of in vitro maturation improves bovine oocyte developmental competence

Treatment with the MAPK kinase inhibitor U0126 during the first two hours of in vitro maturation improves bovine oocyte developmental competence

Contents This study examined the effects of treatment with U0126, which inhibits MAPK by inhibiting MAPK kinase, during the first 2 hr of in vitro maturation on bovine developmental competence and on gap junction (GAPJ) communication between the oocyte and cumulus cells. The percentage of oocytes de...

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Veröffentlicht in:Reproduction in domestic animals 2018-02, Vol.53 (1), p.270-273
Hauptverfasser: Shinohara, T, Ohta, Y, Kawate, N, Takahashi, M, Sakagami, N, Inaba, T, Tamada, H
Format: Artikel
Sprache:eng
Schlagworte:
Animal reproduction
Breakdown
Cattle
Connexin 43
Enzyme inhibitors
Gametocytes
Kinases
MAP kinase
Maturation
Oocytes
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Zusammenfassung:Contents This study examined the effects of treatment with U0126, which inhibits MAPK by inhibiting MAPK kinase, during the first 2 hr of in vitro maturation on bovine developmental competence and on gap junction (GAPJ) communication between the oocyte and cumulus cells. The percentage of oocytes developing to the blastocyst stage in the group treated with 5 μM U0126 (28%) was significantly higher than that in controls (15%, p 
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.13096