Formal Total Synthesis of (+)-C9-Deoxyomuralide from l‑Leucine Using a Double Sacrificial Chirality Transfer Approach

Formal Total Synthesis of (+)-C9-Deoxyomuralide from l‑Leucine Using a Double Sacrificial Chirality Transfer Approach

Formal stereocontrolled syntheses of (±)- and (+)-C9-deoxyomuralide is reported, constituting one of the shortest routes to the full carbon skeleton reported to date.

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Veröffentlicht in:Journal of organic chemistry 2017-12, Vol.82 (23), p.12209-12223
Hauptverfasser: Bulman Page, Philip C, Goodyear, Ross L, Horton, Alexandra E, Chan, Yohan, Karim, Rehana, O’Connell, Maria A, Hamilton, Christopher, Slawin, Alexandra M. Z, Buckley, Benjamin R, Allin, Steven M
Format: Artikel
Sprache:eng
Schlagworte:
Leucine - chemistry
Molecular Structure
Stereoisomerism
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Zusammenfassung:Formal stereocontrolled syntheses of (±)- and (+)-C9-deoxyomuralide is reported, constituting one of the shortest routes to the full carbon skeleton reported to date.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b02078