Real-life experience with hydroxyurea in sickle cell disease: A multicenter study in a cohort of patients with heterogeneous descent

We conducted the first nation-wide cohort study of sickle cell disease (SCD) in Italy, a Southern European country exposed to intense recent flux migration from endemic areas for SCD. We evaluate the impact of hydroxyurea on a total of 652 pediatric and adult patients from 33 Reference Centers for S...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 2018-03, Vol.69, p.82-89
Hauptverfasser:	Rigano, Paolo, De Franceschi, Lucia, Sainati, Laura, Piga, Antonio, Piel, Frédéric B., Cappellini, Maria Domenica, Fidone, Carmelo, Masera, Nicoletta, Palazzi, Giovanni, Gianesin, Barbara, Forni, Gian Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anemia, Sickle Cell - diagnosis Anemia, Sickle Cell - drug therapy Anemia, Sickle Cell - genetics Anemia, Sickle Cell - mortality Antisickling Agents - administration & dosage Antisickling Agents - adverse effects Antisickling Agents - therapeutic use Biomarkers Cause of Death Child Child, Preschool Complications Disease Management Erythrocyte Indices Female Genotype Humans Hydroxycarbamide Hydroxyurea Hydroxyurea - administration & dosage Hydroxyurea - adverse effects Hydroxyurea - therapeutic use Infant Kaplan-Meier Estimate Male Management Middle Aged Real-world Retrospective Studies Sickle cell disease Treatment Outcome Young Adult
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Zusammenfassung:	We conducted the first nation-wide cohort study of sickle cell disease (SCD) in Italy, a Southern European country exposed to intense recent flux migration from endemic areas for SCD. We evaluate the impact of hydroxyurea on a total of 652 pediatric and adult patients from 33 Reference Centers for SCD (mean age 24.5±15years, 51.4% males). Hydroxyurea median treatment duration was 7years (range:
ISSN:	1079-9796 1096-0961
DOI:	10.1016/j.bcmd.2017.08.017