New sesquiterpenes from the red alga Laurencia microcladia
Three new aromatic sesquiterpenes ( 1, 2, and 4), one new dimeric sesquiterpene of the cyclolaurane-type ( 3), one sesquiterpene alcohol of bisabolene type ( 8) along with three previously reported metabolites ( 5– 7), were isolated from the organic extracts of Laurencia microcladia, collected from...
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Veröffentlicht in: | Tetrahedron 2007-08, Vol.63 (32), p.7606-7611 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Three new aromatic sesquiterpenes (
1,
2, and
4), one new dimeric sesquiterpene of the cyclolaurane-type (
3), one sesquiterpene alcohol of bisabolene type (
8) along with three previously reported metabolites (
5–
7), were isolated from the organic extracts of
Laurencia microcladia, collected from the Chios island in the North Aegean Sea. The structures of the new natural products, as well as their relative stereochemistries, were established by means of spectral data analyses, including 2D experiments. The cytotoxicity of the isolated metabolites was evaluated against five human tumor cell lines.
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ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2007.05.051 |