PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release

PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release

To determine neurotoxic mechanisms of PS2 mutation, disruption of cellular calcium homeostasis through ryanodine receptor pathway, interaction between PS2 and ryanodine receptor, and sensitization of neurons to neurotoxicants by activation of caspase-3 activity were investigated in the stably transf...

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Veröffentlicht in:The FASEB journal 2006-01, Vol.20 (1), p.151-153
Hauptverfasser: Lee, Sun Young, Hwang, Dae Youn, Kim, Young Kyu, Lee, Jae Woong, Shin, Im Chul, Oh, Ki Wan, Lee, Myung Koo, Lim, Jong Seok, Yoon, Do Young, Hwang, Se Jin, Hong, Jin Tae
Format: Artikel
Sprache:eng
Schlagworte:
Amyloid beta-Peptides - pharmacology
Animals
Apoptosis - drug effects
Calcium - metabolism
Caspase 3
Caspases - metabolism
Dantrolene - pharmacology
Endoplasmic Reticulum - drug effects
Endoplasmic Reticulum - metabolism
Enzyme Activation - drug effects
Gene Expression Regulation
Genes, Transgenic, Suicide
Glutamic Acid - pharmacology
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mice
Mutation - genetics
Neurons - drug effects
Neurons - enzymology
Neurons - metabolism
Neurotoxins - pharmacology
Neurotoxins - toxicity
PC12 Cells
Presenilin-2
Protein Transport
Rats
Ryanodine Receptor Calcium Release Channel - metabolism
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Zusammenfassung:To determine neurotoxic mechanisms of PS2 mutation, disruption of cellular calcium homeostasis through ryanodine receptor pathway, interaction between PS2 and ryanodine receptor, and sensitization of neurons to neurotoxicants by activation of caspase-3 activity were investigated in the stably transfected PC 12 cells and cortical neurons from transgenic mice expressing wild or mutant PS2 (N141I).
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.05-4017fje