Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma
Median survival for glioblastoma (GBM) remains
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2018-01, Vol.78 (1), p.256-264 |
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| creator | Reap, Elizabeth A Suryadevara, Carter M Batich, Kristen A Sanchez-Perez, Luis Archer, Gary E Schmittling, Robert J Norberg, Pamela K Herndon, 2nd, James E Healy, Patrick Congdon, Kendra L Gedeon, Patrick C Campbell, Olivia C Swartz, Adam M Riccione, Katherine A Yi, John S Hossain-Ibrahim, Mohammed K Saraswathula, Anirudh Nair, Smita K Dunn-Pirio, Anastasie M Broome, Taylor M Weinhold, Kent J Desjardins, Annick Vlahovic, Gordana McLendon, Roger E Friedman, Allan H Friedman, Henry S Bigner, Darell D Fecci, Peter E Mitchell, Duane A Sampson, John H |
| description | Median survival for glioblastoma (GBM) remains |
| doi_str_mv | 10.1158/0008-5472.CAN-17-0469 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1959325319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2006888160</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-76d2b0d79ad3396fd273f2e385ebc9ecb2760a9952aa613daf978414585e41363</originalsourceid><addsrcrecordid>eNpdkU1P3DAQhi1EBQvtT2hliQuXUH_EsX1chU8JtRzC2XJiB4y88dZ2QPn3eMWWA6fRq3ne0cy8APzE6AJjJn4jhETFak4u2vWfCvMK1Y08ACvMqKh4XbNDsPpkjsFJSi9FMozYETgmEkla1Aq8XdrJRJfdAFvrfYJX07OeBgsfgl_GeRqyC5P2Li8wjHBtwja7V-sX2EU9pdHGaA3s9t7uWWfY6fhkM2yXHDb2Sfvw6uKcoJvgjXeh9zqVhv4Ovo3aJ_tjX0_B4_VV195W939v7tr1fTVQUeeKN4b0yHCpDaWyGQ3hdCSWCmb7QdqhJ7xBWkpGtG4wNXqUXNS4ZgWoMW3oKTj_mLuN4d9sU1Ybl4ayrZ5smJPCkklKGMWyoGdf0Jcwx3J8UgShRgiBG1Qo9kENMaQU7ai20W10XBRGapeM2n1d7b6uSjIKc7VLpvh-7afP_caaT9f_KOg7mBeKRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2006888160</pqid></control><display><type>article</type><title>Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Reap, Elizabeth A ; Suryadevara, Carter M ; Batich, Kristen A ; Sanchez-Perez, Luis ; Archer, Gary E ; Schmittling, Robert J ; Norberg, Pamela K ; Herndon, 2nd, James E ; Healy, Patrick ; Congdon, Kendra L ; Gedeon, Patrick C ; Campbell, Olivia C ; Swartz, Adam M ; Riccione, Katherine A ; Yi, John S ; Hossain-Ibrahim, Mohammed K ; Saraswathula, Anirudh ; Nair, Smita K ; Dunn-Pirio, Anastasie M ; Broome, Taylor M ; Weinhold, Kent J ; Desjardins, Annick ; Vlahovic, Gordana ; McLendon, Roger E ; Friedman, Allan H ; Friedman, Henry S ; Bigner, Darell D ; Fecci, Peter E ; Mitchell, Duane A ; Sampson, John H</creator><creatorcontrib>Reap, Elizabeth A ; Suryadevara, Carter M ; Batich, Kristen A ; Sanchez-Perez, Luis ; Archer, Gary E ; Schmittling, Robert J ; Norberg, Pamela K ; Herndon, 2nd, James E ; Healy, Patrick ; Congdon, Kendra L ; Gedeon, Patrick C ; Campbell, Olivia C ; Swartz, Adam M ; Riccione, Katherine A ; Yi, John S ; Hossain-Ibrahim, Mohammed K ; Saraswathula, Anirudh ; Nair, Smita K ; Dunn-Pirio, Anastasie M ; Broome, Taylor M ; Weinhold, Kent J ; Desjardins, Annick ; Vlahovic, Gordana ; McLendon, Roger E ; Friedman, Allan H ; Friedman, Henry S ; Bigner, Darell D ; Fecci, Peter E ; Mitchell, Duane A ; Sampson, John H</creatorcontrib><description>Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recent trial in recurrent GBM patients demonstrated the potential clinical benefit of adoptive T-cell therapy (ATCT) of CMV phosphoprotein 65 (pp65)-specific T cells. However,
analyses from this study found no change in the capacity of CMV pp65-specific T cells to gain multiple effector functions or polyfunctionality, which has been associated with superior antitumor efficacy. Previous studies have shown that dendritic cells (DC) could further enhance tumor-specific CD8
T-cell polyfunctionality
when administered as a vaccine. Therefore, we hypothesized that vaccination with CMV pp65 RNA-loaded DCs would enhance the frequency of polyfunctional CMV pp65-specific CD8
T cells after ATCT. Here, we report prospective results of a pilot trial in which 22 patients with newly diagnosed GBM were initially enrolled, of which 17 patients were randomized to receive CMV pp65-specific T cells with CMV-DC vaccination (CMV-ATCT-DC) or saline (CMV-ATCT-saline). Patients who received CMV-ATCT-DC vaccination experienced a significant increase in the overall frequencies of IFNγ
, TNFα
, and CCL3
polyfunctional, CMV-specific CD8
T cells. These increases in polyfunctional CMV-specific CD8
T cells correlated (
= 0.7371,
= 0.0369) with overall survival, although we cannot conclude this was causally related. Our data implicate polyfunctional T-cell responses as a potential biomarker for effective antitumor immunotherapy and support a formal assessment of this combination approach in a larger randomized study.
A randomized pilot trial in patients with GBM implicates polyfunctional T-cell responses as a biomarker for effective antitumor immunotherapy.
.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.CAN-17-0469</identifier><identifier>PMID: 29093005</identifier><language>eng</language><publisher>United States: American Association for Cancer Research, Inc</publisher><subject>Adoptive Transfer ; Adult ; Aged ; Antigen (tumor-associated) ; Antigens ; Antitumor activity ; Biomarkers ; Brain cancer ; Brain Neoplasms - therapy ; Cancer ; CCL3 protein ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Cytomegalovirus ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Effector cells ; Female ; Glioblastoma ; Glioblastoma - therapy ; Humans ; Immunization ; Immunotherapy ; Immunotherapy, Adoptive - methods ; Lymphocytes ; Lymphocytes T ; Male ; Middle Aged ; Phosphoproteins - metabolism ; Pp65 protein ; Randomization ; Ribonucleic acid ; RNA ; T cell receptors ; T-Lymphocytes - immunology ; T-Lymphocytes - transplantation ; Treatment Outcome ; Tumor necrosis factor-α ; Vaccination ; Viral Matrix Proteins - metabolism ; γ-Interferon</subject><ispartof>Cancer research (Chicago, Ill.), 2018-01, Vol.78 (1), p.256-264</ispartof><rights>2017 American Association for Cancer Research.</rights><rights>Copyright American Association for Cancer Research, Inc. Jan 1, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-76d2b0d79ad3396fd273f2e385ebc9ecb2760a9952aa613daf978414585e41363</citedby><cites>FETCH-LOGICAL-c384t-76d2b0d79ad3396fd273f2e385ebc9ecb2760a9952aa613daf978414585e41363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29093005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reap, Elizabeth A</creatorcontrib><creatorcontrib>Suryadevara, Carter M</creatorcontrib><creatorcontrib>Batich, Kristen A</creatorcontrib><creatorcontrib>Sanchez-Perez, Luis</creatorcontrib><creatorcontrib>Archer, Gary E</creatorcontrib><creatorcontrib>Schmittling, Robert J</creatorcontrib><creatorcontrib>Norberg, Pamela K</creatorcontrib><creatorcontrib>Herndon, 2nd, James E</creatorcontrib><creatorcontrib>Healy, Patrick</creatorcontrib><creatorcontrib>Congdon, Kendra L</creatorcontrib><creatorcontrib>Gedeon, Patrick C</creatorcontrib><creatorcontrib>Campbell, Olivia C</creatorcontrib><creatorcontrib>Swartz, Adam M</creatorcontrib><creatorcontrib>Riccione, Katherine A</creatorcontrib><creatorcontrib>Yi, John S</creatorcontrib><creatorcontrib>Hossain-Ibrahim, Mohammed K</creatorcontrib><creatorcontrib>Saraswathula, Anirudh</creatorcontrib><creatorcontrib>Nair, Smita K</creatorcontrib><creatorcontrib>Dunn-Pirio, Anastasie M</creatorcontrib><creatorcontrib>Broome, Taylor M</creatorcontrib><creatorcontrib>Weinhold, Kent J</creatorcontrib><creatorcontrib>Desjardins, Annick</creatorcontrib><creatorcontrib>Vlahovic, Gordana</creatorcontrib><creatorcontrib>McLendon, Roger E</creatorcontrib><creatorcontrib>Friedman, Allan H</creatorcontrib><creatorcontrib>Friedman, Henry S</creatorcontrib><creatorcontrib>Bigner, Darell D</creatorcontrib><creatorcontrib>Fecci, Peter E</creatorcontrib><creatorcontrib>Mitchell, Duane A</creatorcontrib><creatorcontrib>Sampson, John H</creatorcontrib><title>Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recent trial in recurrent GBM patients demonstrated the potential clinical benefit of adoptive T-cell therapy (ATCT) of CMV phosphoprotein 65 (pp65)-specific T cells. However,
analyses from this study found no change in the capacity of CMV pp65-specific T cells to gain multiple effector functions or polyfunctionality, which has been associated with superior antitumor efficacy. Previous studies have shown that dendritic cells (DC) could further enhance tumor-specific CD8
T-cell polyfunctionality
when administered as a vaccine. Therefore, we hypothesized that vaccination with CMV pp65 RNA-loaded DCs would enhance the frequency of polyfunctional CMV pp65-specific CD8
T cells after ATCT. Here, we report prospective results of a pilot trial in which 22 patients with newly diagnosed GBM were initially enrolled, of which 17 patients were randomized to receive CMV pp65-specific T cells with CMV-DC vaccination (CMV-ATCT-DC) or saline (CMV-ATCT-saline). Patients who received CMV-ATCT-DC vaccination experienced a significant increase in the overall frequencies of IFNγ
, TNFα
, and CCL3
polyfunctional, CMV-specific CD8
T cells. These increases in polyfunctional CMV-specific CD8
T cells correlated (
= 0.7371,
= 0.0369) with overall survival, although we cannot conclude this was causally related. Our data implicate polyfunctional T-cell responses as a potential biomarker for effective antitumor immunotherapy and support a formal assessment of this combination approach in a larger randomized study.
A randomized pilot trial in patients with GBM implicates polyfunctional T-cell responses as a biomarker for effective antitumor immunotherapy.
.</description><subject>Adoptive Transfer</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigen (tumor-associated)</subject><subject>Antigens</subject><subject>Antitumor activity</subject><subject>Biomarkers</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - therapy</subject><subject>Cancer</subject><subject>CCL3 protein</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cytomegalovirus</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Effector cells</subject><subject>Female</subject><subject>Glioblastoma</subject><subject>Glioblastoma - therapy</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunotherapy</subject><subject>Immunotherapy, Adoptive - methods</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phosphoproteins - metabolism</subject><subject>Pp65 protein</subject><subject>Randomization</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>T cell receptors</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - transplantation</subject><subject>Treatment Outcome</subject><subject>Tumor necrosis factor-α</subject><subject>Vaccination</subject><subject>Viral Matrix Proteins - metabolism</subject><subject>γ-Interferon</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1P3DAQhi1EBQvtT2hliQuXUH_EsX1chU8JtRzC2XJiB4y88dZ2QPn3eMWWA6fRq3ne0cy8APzE6AJjJn4jhETFak4u2vWfCvMK1Y08ACvMqKh4XbNDsPpkjsFJSi9FMozYETgmEkla1Aq8XdrJRJfdAFvrfYJX07OeBgsfgl_GeRqyC5P2Li8wjHBtwja7V-sX2EU9pdHGaA3s9t7uWWfY6fhkM2yXHDb2Sfvw6uKcoJvgjXeh9zqVhv4Ovo3aJ_tjX0_B4_VV195W939v7tr1fTVQUeeKN4b0yHCpDaWyGQ3hdCSWCmb7QdqhJ7xBWkpGtG4wNXqUXNS4ZgWoMW3oKTj_mLuN4d9sU1Ybl4ayrZ5smJPCkklKGMWyoGdf0Jcwx3J8UgShRgiBG1Qo9kENMaQU7ai20W10XBRGapeM2n1d7b6uSjIKc7VLpvh-7afP_caaT9f_KOg7mBeKRw</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Reap, Elizabeth A</creator><creator>Suryadevara, Carter M</creator><creator>Batich, Kristen A</creator><creator>Sanchez-Perez, Luis</creator><creator>Archer, Gary E</creator><creator>Schmittling, Robert J</creator><creator>Norberg, Pamela K</creator><creator>Herndon, 2nd, James E</creator><creator>Healy, Patrick</creator><creator>Congdon, Kendra L</creator><creator>Gedeon, Patrick C</creator><creator>Campbell, Olivia C</creator><creator>Swartz, Adam M</creator><creator>Riccione, Katherine A</creator><creator>Yi, John S</creator><creator>Hossain-Ibrahim, Mohammed K</creator><creator>Saraswathula, Anirudh</creator><creator>Nair, Smita K</creator><creator>Dunn-Pirio, Anastasie M</creator><creator>Broome, Taylor M</creator><creator>Weinhold, Kent J</creator><creator>Desjardins, Annick</creator><creator>Vlahovic, Gordana</creator><creator>McLendon, Roger E</creator><creator>Friedman, Allan H</creator><creator>Friedman, Henry S</creator><creator>Bigner, Darell D</creator><creator>Fecci, Peter E</creator><creator>Mitchell, Duane A</creator><creator>Sampson, John H</creator><general>American Association for Cancer Research, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma</title><author>Reap, Elizabeth A ; Suryadevara, Carter M ; Batich, Kristen A ; Sanchez-Perez, Luis ; Archer, Gary E ; Schmittling, Robert J ; Norberg, Pamela K ; Herndon, 2nd, James E ; Healy, Patrick ; Congdon, Kendra L ; Gedeon, Patrick C ; Campbell, Olivia C ; Swartz, Adam M ; Riccione, Katherine A ; Yi, John S ; Hossain-Ibrahim, Mohammed K ; Saraswathula, Anirudh ; Nair, Smita K ; Dunn-Pirio, Anastasie M ; Broome, Taylor M ; Weinhold, Kent J ; Desjardins, Annick ; Vlahovic, Gordana ; McLendon, Roger E ; Friedman, Allan H ; Friedman, Henry S ; Bigner, Darell D ; Fecci, Peter E ; Mitchell, Duane A ; Sampson, John H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-76d2b0d79ad3396fd273f2e385ebc9ecb2760a9952aa613daf978414585e41363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adoptive Transfer</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigen (tumor-associated)</topic><topic>Antigens</topic><topic>Antitumor activity</topic><topic>Biomarkers</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - therapy</topic><topic>Cancer</topic><topic>CCL3 protein</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cytomegalovirus</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Effector cells</topic><topic>Female</topic><topic>Glioblastoma</topic><topic>Glioblastoma - therapy</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunotherapy</topic><topic>Immunotherapy, Adoptive - methods</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phosphoproteins - metabolism</topic><topic>Pp65 protein</topic><topic>Randomization</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>T cell receptors</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - transplantation</topic><topic>Treatment Outcome</topic><topic>Tumor necrosis factor-α</topic><topic>Vaccination</topic><topic>Viral Matrix Proteins - 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Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reap, Elizabeth A</au><au>Suryadevara, Carter M</au><au>Batich, Kristen A</au><au>Sanchez-Perez, Luis</au><au>Archer, Gary E</au><au>Schmittling, Robert J</au><au>Norberg, Pamela K</au><au>Herndon, 2nd, James E</au><au>Healy, Patrick</au><au>Congdon, Kendra L</au><au>Gedeon, Patrick C</au><au>Campbell, Olivia C</au><au>Swartz, Adam M</au><au>Riccione, Katherine A</au><au>Yi, John S</au><au>Hossain-Ibrahim, Mohammed K</au><au>Saraswathula, Anirudh</au><au>Nair, Smita K</au><au>Dunn-Pirio, Anastasie M</au><au>Broome, Taylor M</au><au>Weinhold, Kent J</au><au>Desjardins, Annick</au><au>Vlahovic, Gordana</au><au>McLendon, Roger E</au><au>Friedman, Allan H</au><au>Friedman, Henry S</au><au>Bigner, Darell D</au><au>Fecci, Peter E</au><au>Mitchell, Duane A</au><au>Sampson, John H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>78</volume><issue>1</issue><spage>256</spage><epage>264</epage><pages>256-264</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><abstract>Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recent trial in recurrent GBM patients demonstrated the potential clinical benefit of adoptive T-cell therapy (ATCT) of CMV phosphoprotein 65 (pp65)-specific T cells. However,
analyses from this study found no change in the capacity of CMV pp65-specific T cells to gain multiple effector functions or polyfunctionality, which has been associated with superior antitumor efficacy. Previous studies have shown that dendritic cells (DC) could further enhance tumor-specific CD8
T-cell polyfunctionality
when administered as a vaccine. Therefore, we hypothesized that vaccination with CMV pp65 RNA-loaded DCs would enhance the frequency of polyfunctional CMV pp65-specific CD8
T cells after ATCT. Here, we report prospective results of a pilot trial in which 22 patients with newly diagnosed GBM were initially enrolled, of which 17 patients were randomized to receive CMV pp65-specific T cells with CMV-DC vaccination (CMV-ATCT-DC) or saline (CMV-ATCT-saline). Patients who received CMV-ATCT-DC vaccination experienced a significant increase in the overall frequencies of IFNγ
, TNFα
, and CCL3
polyfunctional, CMV-specific CD8
T cells. These increases in polyfunctional CMV-specific CD8
T cells correlated (
= 0.7371,
= 0.0369) with overall survival, although we cannot conclude this was causally related. Our data implicate polyfunctional T-cell responses as a potential biomarker for effective antitumor immunotherapy and support a formal assessment of this combination approach in a larger randomized study.
A randomized pilot trial in patients with GBM implicates polyfunctional T-cell responses as a biomarker for effective antitumor immunotherapy.
.</abstract><cop>United States</cop><pub>American Association for Cancer Research, Inc</pub><pmid>29093005</pmid><doi>10.1158/0008-5472.CAN-17-0469</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 2018-01, Vol.78 (1), p.256-264 |
| issn | 0008-5472 1538-7445 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1959325319 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adoptive Transfer Adult Aged Antigen (tumor-associated) Antigens Antitumor activity Biomarkers Brain cancer Brain Neoplasms - therapy Cancer CCL3 protein CD8 antigen CD8-Positive T-Lymphocytes - immunology Cytomegalovirus Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Effector cells Female Glioblastoma Glioblastoma - therapy Humans Immunization Immunotherapy Immunotherapy, Adoptive - methods Lymphocytes Lymphocytes T Male Middle Aged Phosphoproteins - metabolism Pp65 protein Randomization Ribonucleic acid RNA T cell receptors T-Lymphocytes - immunology T-Lymphocytes - transplantation Treatment Outcome Tumor necrosis factor-α Vaccination Viral Matrix Proteins - metabolism γ-Interferon |
| title | Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T02%3A40%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dendritic%20Cells%20Enhance%20Polyfunctionality%20of%20Adoptively%20Transferred%20T%20Cells%20That%20Target%20Cytomegalovirus%20in%20Glioblastoma&rft.jtitle=Cancer%20research%20(Chicago,%20Ill.)&rft.au=Reap,%20Elizabeth%20A&rft.date=2018-01-01&rft.volume=78&rft.issue=1&rft.spage=256&rft.epage=264&rft.pages=256-264&rft.issn=0008-5472&rft.eissn=1538-7445&rft_id=info:doi/10.1158/0008-5472.CAN-17-0469&rft_dat=%3Cproquest_cross%3E2006888160%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2006888160&rft_id=info:pmid/29093005&rfr_iscdi=true |