Primary metastatic osteosarcoma: results of a prospective study in children given chemotherapy and interleukin-2

Primary metastatic osteosarcoma: results of a prospective study in children given chemotherapy and interleukin-2

To improve the poor prognosis for children with metastatic osteosarcoma (OS), interleukin-2 (IL-2) was added to the standard treatment due to its capacity to activate lymphocytes and differentiate lymphocyte subsets into lymphokine-activated killer (LAK) cells that are capable of recognizing and kil...

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Veröffentlicht in:Medical oncology (Northwood, London, England) London, England), 2017-12, Vol.34 (12), p.191-8, Article 191
Hauptverfasser: Meazza, Cristina, Cefalo, Graziella, Massimino, Maura, Daolio, Primo, Pastorino, Ugo, Scanagatta, Paolo, Morosi, Carlo, Podda, Marta, Ferrari, Andrea, Terenziani, Monica, Spreafico, Filippo, Casanova, Michela, Parafioriti, Antonina, Collini, Paola, Gandola, Lorenza, Bastoni, Stefano, Biassoni, Veronica, Schiavello, Elisabetta, Chiaravalli, Stefano, Puma, Nadia, Bergamaschi, Luca, Luksch, Roberto
Format: Artikel
Sprache:eng
Schlagworte:
Bone cancer
Chemotherapy
Cytokines
Hematology
Internal Medicine
Lung cancer
Medical prognosis
Medicine
Medicine & Public Health
Metastasis
Oncology
Original Paper
Pathology
Sarcoma
Surgery
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Zusammenfassung:To improve the poor prognosis for children with metastatic osteosarcoma (OS), interleukin-2 (IL-2) was added to the standard treatment due to its capacity to activate lymphocytes and differentiate lymphocyte subsets into lymphokine-activated killer (LAK) cells that are capable of recognizing and killing various tumor cells. This study concerns a cohort of unselected patients aged
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-017-1052-9