Improved Synthesis of Nigricanin

An ellagic acid-related natural product, nigricanin (1), was synthesized via the Ullmann coupling reaction of 2-bromo-3,4-dialkoxybenzaldehyde (4) followed by the Cannizzaro reaction for desymmetrization of the symmetric biaryl compound (5). Compared to our previously reported study, the presented s...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2017/11/01, Vol.65(11), pp.1078-1080
Hauptverfasser:	Abe, Hitoshi, Nagai, Takanori, Imai, Haruka, Horino, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemical synthesis Biological Products - chemistry Cannizzaro reaction Chemical reactions Chemical synthesis Ellagic acid Ellagic Acid - analogs & derivatives Ellagic Acid - chemical synthesis Ellagic Acid - chemistry Molecular Structure Natural products Russula nigricans Ullmann coupling
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Zusammenfassung:	An ellagic acid-related natural product, nigricanin (1), was synthesized via the Ullmann coupling reaction of 2-bromo-3,4-dialkoxybenzaldehyde (4) followed by the Cannizzaro reaction for desymmetrization of the symmetric biaryl compound (5). Compared to our previously reported study, the presented synthesis improved the sequence step number.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c17-00448