Development of Mitral Stenosis After Mitral Valve Repair: Importance of Mitral Valve Area
The development of mitral stenosis (MS) is not uncommon after mitral valve (MV) repair for degenerative mitral regurgitation (MR), but the significance of MS in this setting has not been defined. We prospectively studied 110 such patients who underwent supine bicycle exercise testing to assess intra...
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Veröffentlicht in: | Canadian journal of cardiology 2017-12, Vol.33 (12), p.1701-1707 |
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Zusammenfassung: | The development of mitral stenosis (MS) is not uncommon after mitral valve (MV) repair for degenerative mitral regurgitation (MR), but the significance of MS in this setting has not been defined.
We prospectively studied 110 such patients who underwent supine bicycle exercise testing to assess intracardiac hemodynamics at rest and at peak exercise. B-type natriuretic peptide (BNP) levels were measured at rest and after the exercise test. The patients also performed the 6-minute walk test and completed the 36-Item Short Form Survey (SF-36). Follow-up was performed by a review of the medical record and telephone interview.
Of 110 patients, 22 had MS defined by a mitral valve area (MVA) ≤ 1.5 cm2. The resting and peak exercise mitral gradients and pulmonary artery systolic pressure were significantly higher in patients with MS compared with patients with an MVA > 1.5 cm2. BNP levels at rest and after exercise were also higher in the patients with MS, who also had lower exercise capacity and worse perception of well-being in 3 domains (physical function, vitality, and social function) on the SF-36. MVA had higher specificity and positive predictive value in predicting outcome events compared with a mean gradient of 3 or 5 mm Hg.
In patients who had MV repair for degenerative MR, an MVA ≤ 1.5 cm2 occurs in about one-fifth of patients and is associated with adverse intracardiac hemodynamics, lower exercise capacity, and adverse outcomes.
Il n’est pas inhabituel de développer une sténose mitrale (SM) après la réparation de la valve mitrale (VM) en raison d’une régurgitation mitrale (RM) dégénérative, mais l’importance de la SM dans ce contexte n’a pas été établie.
Nous avons étudié de manière prospective 110 patients qui avaient subi une épreuve à l’effort sur bicyclette en position allongée pour évaluer l’hémodynamique intracardiaque au repos et à l’effort maximal. Nous avons mesuré les concentrations du peptide natriurétique de type B (BNP) au repos et après l’épreuve d’effort. Les patients ont également réalisé le test de marche de 6 minutes et rempli le questionnaire abrégé de 36 items (SF-36). Nous avons eu recours à la revue du dossier médical et à l’entretien téléphonique pour effectuer le suivi.
Parmi les 110 patients, 22 avaient une SM définie par une surface valvulaire mitrale (SVM) ≤ 1,5 cm2. Les gradients mitraux au repos et à l’effort maximal et la pression artérielle pulmonaire systolique étaient significativement plus élevés chez les patients attei |
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ISSN: | 0828-282X 1916-7075 |
DOI: | 10.1016/j.cjca.2017.08.027 |