Oxidation Reduction Potential (ORP) is Predictive of Complications Following Pediatric Cardiac Surgery

Oxidation Reduction Potential (ORP) is Predictive of Complications Following Pediatric Cardiac Surgery

Oxidation reduction potential (ORP) or Redox is the ratio of activity between oxidizers and reducers. Oxidative stress (OS) can cause cellular injury and death, and is important in the regulation of immune response to injury or disease. In the present study, we investigated changes in the redox syst...

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Veröffentlicht in:Pediatric cardiology 2018-02, Vol.39 (2), p.299-306
Hauptverfasser: Schmidt, Amy E., Gore, Emily, Henrichs, Kelly F., Conley, Grace, Dorsey, Charles, Bjugstad, Kimberly B., Refaai, Majed A., Blumberg, Neil, Cholette, Jill M.
Format: Artikel
Sprache:eng
Schlagworte:
Cardiac patients
Cardiac Surgery
Cardiology
Children
Coronary artery bypass
Haptoglobin
Health aspects
Immune response
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Original Article
Oxidation-reduction reaction
Pediatric cardiology
Surgery
Vascular Surgery
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Zusammenfassung:Oxidation reduction potential (ORP) or Redox is the ratio of activity between oxidizers and reducers. Oxidative stress (OS) can cause cellular injury and death, and is important in the regulation of immune response to injury or disease. In the present study, we investigated changes in the redox system as a function of cardiopulmonary bypass (CPB) in pediatric patients. 664 plasma samples were collected from 162 pediatric patients having cardiac surgery of various CPB times. Lower ORP values at 12 h post-CPB were associated with poor survival rate (mean ± SD 167 ± 20 vs. 138 ± 19, p  = 0.005) and higher rate of thrombotic complications (153 ± 21 vs. 168 ± 20, p  
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-017-1755-x