Transdisciplinary Research on Energetics and Cancer: From Adipose Tissue to the American Society of Clinical Oncology (ASCO) Summit Recommendations

In 2003, The New England Journal of Medicine published a landmark paper by Dr. Eugenia Calle that documented increased risk of death from a broad number of cancers among adults with obesity, as compared to normal weight adults (1). TREC science contributions include establishing effects of exercise and weight loss on biomarkers for breast cancer among pre- and postmenopausal women (15,16), documented improvement in chemotherapy treatment outcomes in mice (17), and documentation that the mechanism for exercise to alter chemotherapy outcomes may be normalization of vasculature (18). [...]there are four epidemiologic analyses that evaluate the effects of bariatric surgery on subsequent cancer risk (23), inflammation on the effect of obesity on vitamin D levels (24), cardiorespiratory fitness on cancer deaths among veterans with obesity (25), and the potential for easily assessed clinical parameters to define groups at high risk for colorectal cancer (26). [...]three intervention studies report effects of dietary and physical activity interventions among adults with obesity (29), endometrial cancer survivors (30), and breast cancer survivors (31).