Synthesis and antiarrhythmic properties of N-acylamino derivatives of 1,6,7-substituted 1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their analogs
Aseries of new N-chloracetyl derivatives have been synthesized proceeding from 4-spirocyclopentane-substituted 1,2,3,4-tetrahydroisoquinolines, 1-phenyl-1-cyclopentylmethylamine, and chloroanhydrides of bromoacetic and alpha -bromopropionic acids. Reactions of these bromoamides with amines (piperidi...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2006-07, Vol.40 (7), p.360-362 |
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| container_title | Pharmaceutical chemistry journal |
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| creator | Markaryan, É. A. Arustamyan, Zh. S. Avetisyan, S. V. Markaryan, R. É. Markaryan, K. Zh Asatryan, T. O. Grigoryan, A. V. |
| description | Aseries of new N-chloracetyl derivatives have been synthesized proceeding from 4-spirocyclopentane-substituted 1,2,3,4-tetrahydroisoquinolines, 1-phenyl-1-cyclopentylmethylamine, and chloroanhydrides of bromoacetic and alpha -bromopropionic acids. Reactions of these bromoamides with amines (piperidine, morpholine) yield the title N-acylamino derivatives. The antiarrhythmic properties of the synthesized compounds have been studied. |
| doi_str_mv | 10.1007/s11094-006-0127-2 |
| format | Article |
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| ispartof | Pharmaceutical chemistry journal, 2006-07, Vol.40 (7), p.360-362 |
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| language | eng |
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| title | Synthesis and antiarrhythmic properties of N-acylamino derivatives of 1,6,7-substituted 1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their analogs |
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