Synthesis and antiarrhythmic properties of N-acylamino derivatives of 1,6,7-substituted 1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their analogs

Aseries of new N-chloracetyl derivatives have been synthesized proceeding from 4-spirocyclopentane-substituted 1,2,3,4-tetrahydroisoquinolines, 1-phenyl-1-cyclopentylmethylamine, and chloroanhydrides of bromoacetic and alpha -bromopropionic acids. Reactions of these bromoamides with amines (piperidine, morpholine) yield the title N-acylamino derivatives. The antiarrhythmic properties of the synthesized compounds have been studied.