A comparison of estimates of doses to radiotherapy patients obtained with the dicentric chromosome analysis and the γ-H2AX assay: Relevance to radiation triage

A comparison of estimates of doses to radiotherapy patients obtained with the dicentric chromosome analysis and the γ-H2AX assay: Relevance to radiation triage

The γ-H2AX assay was investigated as an alternative to the time-consuming dicentric chromosome assay (DCA). Radiation doses to 25 radiotherapy patients were estimated in parallel by DCA and the γ-H2AX assay. The γ-H2AX assay yielded doses in line with the calculated equivalent whole body doses in 92...

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Veröffentlicht in:Applied radiation and isotopes 2018-01, Vol.131, p.1-7
Hauptverfasser: Manivannan, Bhavani, Kuppusamy, Thayalan, Venkatesan, Srinivasan, Perumal, Venkatachalam
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Case-Control Studies
Chromosome Aberrations
Female
Histones - blood
Histones - genetics
Humans
Male
Middle Aged
Neoplasms - radiotherapy
Radiometry - methods
Radiotherapy Dosage
Reproducibility of Results
Whole-Body Irradiation
Young Adult
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Zusammenfassung:The γ-H2AX assay was investigated as an alternative to the time-consuming dicentric chromosome assay (DCA). Radiation doses to 25 radiotherapy patients were estimated in parallel by DCA and the γ-H2AX assay. The γ-H2AX assay yielded doses in line with the calculated equivalent whole body doses in 92% of the patients, whereas the success rate of DCA was only 76%. The result shows that the γ-H2AX assay can be effectively used as a rapid and more precise alternative to DCA.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2017.10.031