Suppression of microRNA-454 impedes the proliferation and invasion of prostate cancer cells by promoting N-myc downstream-regulated gene 2 and inhibiting WNT/β-catenin signaling

MicroRNA-454 (miR-454) is emerging as critical regulator in tumorigenesis; it may function as an oncogene or a tumor suppressor. However, the role of miR-454 in prostate cancer remains unknown. In this study, we aimed to investigate the function and molecular mechanisms of miR-454 in prostate cancer...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2018-01, Vol.97, p.120-127
Hauptverfasser:	Fu, Qiang, Gao, Yanyao, Yang, Fan, Mao, Tianci, Sun, Zhenye, Wang, He, Song, Bin, Li, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin - antagonists & inhibitors beta Catenin - metabolism Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - physiology Humans Male MicroRNAs - antagonists & inhibitors MicroRNAs - biosynthesis MicroRNAs - genetics miR-454 NDRG2 Neoplasm Invasiveness - genetics Neoplasm Invasiveness - prevention & control Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism RNA, Small Interfering - pharmacology Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics WNT Wnt Signaling Pathway - drug effects Wnt Signaling Pathway - physiology
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Zusammenfassung:	MicroRNA-454 (miR-454) is emerging as critical regulator in tumorigenesis; it may function as an oncogene or a tumor suppressor. However, the role of miR-454 in prostate cancer remains unknown. In this study, we aimed to investigate the function and molecular mechanisms of miR-454 in prostate cancer. We found that miR-454 was highly expressed in prostate cancer tissues and cell lines (*p
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.10.115