Divergent evolutionary trajectories in transplanted tumor models

Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2017-11, Vol.49 (11), p.1565-1566
Hauptverfasser:	Villacorta-Martin, Carlos, Craig, Amanda J, Villanueva, Augusto
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 692/308/1426 Agriculture Animal Genetics and Genomics Animals Biomedicine Cancer Research Carcinogenesis Clinical trials Clonal Evolution Clone Cells Disease Models, Animal DNA Copy Number Variations DNA, Neoplasm - genetics DNA, Neoplasm - immunology Forecasts and trends Gene Function Heterografts - immunology Heterografts - pathology Human Genetics Humans Immunocompromised Host Medical journalism Mice Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology news-and-views Precision Medicine Species Specificity Tumor Cells, Cultured Xenotransplantation
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Beschreibung
Zusammenfassung:	Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.3983