Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery
Examination of approximately 10,000 specimens obtained during surgery for intractable seizures in children and adults resulted in 36 distinct diagnoses in seven categories; the most common diagnoses were hippocampal sclerosis, ganglioglioma, and focal cortical dysplasia.
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| Veröffentlicht in: | The New England journal of medicine 2017-10, Vol.377 (17), p.1648-1656 |
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| container_title | The New England journal of medicine |
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| creator | Blumcke, Ingmar Spreafico, Roberto Haaker, Gerrit Coras, Roland Kobow, Katja Bien, Christian G Pfäfflin, Margarete Elger, Christian Widman, Guido Schramm, Johannes Becker, Albert Braun, Kees P Leijten, Frans Baayen, Johannes C Aronica, Eleonora Chassoux, Francine Hamer, Hajo Stefan, Hermann Rössler, Karl Thom, Maria Walker, Matthew C Sisodiya, Sanjay M Duncan, John S McEvoy, Andrew W Pieper, Tom Holthausen, Hans Kudernatsch, Manfred Meencke, H. Joachim Kahane, Philippe Schulze-Bonhage, Andreas Zentner, Josef Heiland, Dieter H Urbach, Horst Steinhoff, Bernhard J Bast, Thomas Tassi, Laura Lo Russo, Giorgio Özkara, Cigdem Oz, Buge Krsek, Pavel Vogelgesang, Silke Runge, Uwe Lerche, Holger Weber, Yvonne Honavar, Mrinalini Pimentel, José Arzimanoglou, Alexis Ulate-Campos, Adriana Noachtar, Soheyl Hartl, Elisabeth Schijns, Olaf Guerrini, Renzo Barba, Carmen Jacques, Thomas S Cross, J. Helen Feucht, Martha Mühlebner, Angelika Grunwald, Thomas Trinka, Eugen Winkler, Peter A Gil-Nagel, Antonio Toledano Delgado, Rafael Mayer, Thomas Lutz, Martin Zountsas, Basilios Garganis, Kyriakos Rosenow, Felix Hermsen, Anke von Oertzen, Tim J Diepgen, Thomas L Avanzini, Giuliano |
| description | Examination of approximately 10,000 specimens obtained during surgery for intractable seizures in children and adults resulted in 36 distinct diagnoses in seven categories; the most common diagnoses were hippocampal sclerosis, ganglioglioma, and focal cortical dysplasia. |
| doi_str_mv | 10.1056/NEJMoa1703784 |
| format | Article |
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Joachim ; Kahane, Philippe ; Schulze-Bonhage, Andreas ; Zentner, Josef ; Heiland, Dieter H ; Urbach, Horst ; Steinhoff, Bernhard J ; Bast, Thomas ; Tassi, Laura ; Lo Russo, Giorgio ; Özkara, Cigdem ; Oz, Buge ; Krsek, Pavel ; Vogelgesang, Silke ; Runge, Uwe ; Lerche, Holger ; Weber, Yvonne ; Honavar, Mrinalini ; Pimentel, José ; Arzimanoglou, Alexis ; Ulate-Campos, Adriana ; Noachtar, Soheyl ; Hartl, Elisabeth ; Schijns, Olaf ; Guerrini, Renzo ; Barba, Carmen ; Jacques, Thomas S ; Cross, J. Helen ; Feucht, Martha ; Mühlebner, Angelika ; Grunwald, Thomas ; Trinka, Eugen ; Winkler, Peter A ; Gil-Nagel, Antonio ; Toledano Delgado, Rafael ; Mayer, Thomas ; Lutz, Martin ; Zountsas, Basilios ; Garganis, Kyriakos ; Rosenow, Felix ; Hermsen, Anke ; von Oertzen, Tim J ; Diepgen, Thomas L ; Avanzini, Giuliano</creator><creatorcontrib>Blumcke, Ingmar ; Spreafico, Roberto ; Haaker, Gerrit ; Coras, Roland ; Kobow, Katja ; Bien, Christian G ; Pfäfflin, Margarete ; Elger, Christian ; Widman, Guido ; Schramm, Johannes ; Becker, Albert ; Braun, Kees P ; Leijten, Frans ; Baayen, Johannes C ; Aronica, Eleonora ; Chassoux, Francine ; Hamer, Hajo ; Stefan, Hermann ; Rössler, Karl ; Thom, Maria ; Walker, Matthew C ; Sisodiya, Sanjay M ; Duncan, John S ; McEvoy, Andrew W ; Pieper, Tom ; Holthausen, Hans ; Kudernatsch, Manfred ; Meencke, H. Joachim ; Kahane, Philippe ; Schulze-Bonhage, Andreas ; Zentner, Josef ; Heiland, Dieter H ; Urbach, Horst ; Steinhoff, Bernhard J ; Bast, Thomas ; Tassi, Laura ; Lo Russo, Giorgio ; Özkara, Cigdem ; Oz, Buge ; Krsek, Pavel ; Vogelgesang, Silke ; Runge, Uwe ; Lerche, Holger ; Weber, Yvonne ; Honavar, Mrinalini ; Pimentel, José ; Arzimanoglou, Alexis ; Ulate-Campos, Adriana ; Noachtar, Soheyl ; Hartl, Elisabeth ; Schijns, Olaf ; Guerrini, Renzo ; Barba, Carmen ; Jacques, Thomas S ; Cross, J. Helen ; Feucht, Martha ; Mühlebner, Angelika ; Grunwald, Thomas ; Trinka, Eugen ; Winkler, Peter A ; Gil-Nagel, Antonio ; Toledano Delgado, Rafael ; Mayer, Thomas ; Lutz, Martin ; Zountsas, Basilios ; Garganis, Kyriakos ; Rosenow, Felix ; Hermsen, Anke ; von Oertzen, Tim J ; Diepgen, Thomas L ; Avanzini, Giuliano ; EEBB Consortium</creatorcontrib><description>Examination of approximately 10,000 specimens obtained during surgery for intractable seizures in children and adults resulted in 36 distinct diagnoses in seven categories; the most common diagnoses were hippocampal sclerosis, ganglioglioma, and focal cortical dysplasia.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1703784</identifier><identifier>PMID: 29069555</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Age Factors ; Age of Onset ; Brain - pathology ; Brain Neoplasms - complications ; Brain Neoplasms - pathology ; Child ; Children ; Cortex ; Databases as Topic ; Drug resistance ; Dysplasia ; Epilepsy ; Epilepsy - etiology ; Epilepsy - pathology ; Epilepsy - surgery ; Europe ; Female ; Hippocampus ; Hippocampus - pathology ; Histopathology ; Humans ; Male ; Malformations of Cortical Development - complications ; Malformations of Cortical Development - pathology ; Neurology ; Neuropathology ; Neurosurgery ; NMR ; Nuclear magnetic resonance ; Patients ; Pediatrics ; Sclerosis ; Seizures ; Surgery ; Temporal lobe ; Temporal Lobe - pathology ; Tumors</subject><ispartof>The New England journal of medicine, 2017-10, Vol.377 (17), p.1648-1656</ispartof><rights>Copyright © 2017 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-8bf763f5705b85340fee636cd44481607c133d773586a90eb110ed140d703e1e3</citedby><cites>FETCH-LOGICAL-c500t-8bf763f5705b85340fee636cd44481607c133d773586a90eb110ed140d703e1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1703784$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1955657247?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29069555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blumcke, Ingmar</creatorcontrib><creatorcontrib>Spreafico, Roberto</creatorcontrib><creatorcontrib>Haaker, Gerrit</creatorcontrib><creatorcontrib>Coras, Roland</creatorcontrib><creatorcontrib>Kobow, Katja</creatorcontrib><creatorcontrib>Bien, Christian G</creatorcontrib><creatorcontrib>Pfäfflin, Margarete</creatorcontrib><creatorcontrib>Elger, Christian</creatorcontrib><creatorcontrib>Widman, Guido</creatorcontrib><creatorcontrib>Schramm, Johannes</creatorcontrib><creatorcontrib>Becker, Albert</creatorcontrib><creatorcontrib>Braun, Kees P</creatorcontrib><creatorcontrib>Leijten, Frans</creatorcontrib><creatorcontrib>Baayen, Johannes C</creatorcontrib><creatorcontrib>Aronica, Eleonora</creatorcontrib><creatorcontrib>Chassoux, Francine</creatorcontrib><creatorcontrib>Hamer, Hajo</creatorcontrib><creatorcontrib>Stefan, Hermann</creatorcontrib><creatorcontrib>Rössler, Karl</creatorcontrib><creatorcontrib>Thom, Maria</creatorcontrib><creatorcontrib>Walker, Matthew C</creatorcontrib><creatorcontrib>Sisodiya, Sanjay M</creatorcontrib><creatorcontrib>Duncan, John S</creatorcontrib><creatorcontrib>McEvoy, Andrew W</creatorcontrib><creatorcontrib>Pieper, Tom</creatorcontrib><creatorcontrib>Holthausen, Hans</creatorcontrib><creatorcontrib>Kudernatsch, Manfred</creatorcontrib><creatorcontrib>Meencke, H. 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Joachim ; Kahane, Philippe ; Schulze-Bonhage, Andreas ; Zentner, Josef ; Heiland, Dieter H ; Urbach, Horst ; Steinhoff, Bernhard J ; Bast, Thomas ; Tassi, Laura ; Lo Russo, Giorgio ; Özkara, Cigdem ; Oz, Buge ; Krsek, Pavel ; Vogelgesang, Silke ; Runge, Uwe ; Lerche, Holger ; Weber, Yvonne ; Honavar, Mrinalini ; Pimentel, José ; Arzimanoglou, Alexis ; Ulate-Campos, Adriana ; Noachtar, Soheyl ; Hartl, Elisabeth ; Schijns, Olaf ; Guerrini, Renzo ; Barba, Carmen ; Jacques, Thomas S ; Cross, J. Helen ; Feucht, Martha ; Mühlebner, Angelika ; Grunwald, Thomas ; Trinka, Eugen ; Winkler, Peter A ; Gil-Nagel, Antonio ; Toledano Delgado, Rafael ; Mayer, Thomas ; Lutz, Martin ; Zountsas, Basilios ; Garganis, Kyriakos ; Rosenow, Felix ; Hermsen, Anke ; von Oertzen, Tim J ; Diepgen, Thomas L ; Avanzini, Giuliano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-8bf763f5705b85340fee636cd44481607c133d773586a90eb110ed140d703e1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - complications</topic><topic>Brain Neoplasms - pathology</topic><topic>Child</topic><topic>Children</topic><topic>Cortex</topic><topic>Databases as Topic</topic><topic>Drug resistance</topic><topic>Dysplasia</topic><topic>Epilepsy</topic><topic>Epilepsy - etiology</topic><topic>Epilepsy - pathology</topic><topic>Epilepsy - surgery</topic><topic>Europe</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - pathology</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Malformations of Cortical Development - complications</topic><topic>Malformations of Cortical Development - pathology</topic><topic>Neurology</topic><topic>Neuropathology</topic><topic>Neurosurgery</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Sclerosis</topic><topic>Seizures</topic><topic>Surgery</topic><topic>Temporal lobe</topic><topic>Temporal Lobe - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blumcke, Ingmar</creatorcontrib><creatorcontrib>Spreafico, Roberto</creatorcontrib><creatorcontrib>Haaker, Gerrit</creatorcontrib><creatorcontrib>Coras, Roland</creatorcontrib><creatorcontrib>Kobow, Katja</creatorcontrib><creatorcontrib>Bien, Christian G</creatorcontrib><creatorcontrib>Pfäfflin, Margarete</creatorcontrib><creatorcontrib>Elger, Christian</creatorcontrib><creatorcontrib>Widman, Guido</creatorcontrib><creatorcontrib>Schramm, Johannes</creatorcontrib><creatorcontrib>Becker, Albert</creatorcontrib><creatorcontrib>Braun, Kees P</creatorcontrib><creatorcontrib>Leijten, Frans</creatorcontrib><creatorcontrib>Baayen, Johannes C</creatorcontrib><creatorcontrib>Aronica, Eleonora</creatorcontrib><creatorcontrib>Chassoux, Francine</creatorcontrib><creatorcontrib>Hamer, Hajo</creatorcontrib><creatorcontrib>Stefan, Hermann</creatorcontrib><creatorcontrib>Rössler, Karl</creatorcontrib><creatorcontrib>Thom, Maria</creatorcontrib><creatorcontrib>Walker, Matthew C</creatorcontrib><creatorcontrib>Sisodiya, Sanjay M</creatorcontrib><creatorcontrib>Duncan, John S</creatorcontrib><creatorcontrib>McEvoy, Andrew W</creatorcontrib><creatorcontrib>Pieper, Tom</creatorcontrib><creatorcontrib>Holthausen, Hans</creatorcontrib><creatorcontrib>Kudernatsch, Manfred</creatorcontrib><creatorcontrib>Meencke, H. 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Helen</creatorcontrib><creatorcontrib>Feucht, Martha</creatorcontrib><creatorcontrib>Mühlebner, Angelika</creatorcontrib><creatorcontrib>Grunwald, Thomas</creatorcontrib><creatorcontrib>Trinka, Eugen</creatorcontrib><creatorcontrib>Winkler, Peter A</creatorcontrib><creatorcontrib>Gil-Nagel, Antonio</creatorcontrib><creatorcontrib>Toledano Delgado, Rafael</creatorcontrib><creatorcontrib>Mayer, Thomas</creatorcontrib><creatorcontrib>Lutz, Martin</creatorcontrib><creatorcontrib>Zountsas, Basilios</creatorcontrib><creatorcontrib>Garganis, Kyriakos</creatorcontrib><creatorcontrib>Rosenow, Felix</creatorcontrib><creatorcontrib>Hermsen, Anke</creatorcontrib><creatorcontrib>von Oertzen, Tim J</creatorcontrib><creatorcontrib>Diepgen, Thomas L</creatorcontrib><creatorcontrib>Avanzini, Giuliano</creatorcontrib><creatorcontrib>EEBB Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blumcke, Ingmar</au><au>Spreafico, Roberto</au><au>Haaker, Gerrit</au><au>Coras, Roland</au><au>Kobow, Katja</au><au>Bien, Christian G</au><au>Pfäfflin, Margarete</au><au>Elger, Christian</au><au>Widman, Guido</au><au>Schramm, Johannes</au><au>Becker, Albert</au><au>Braun, Kees P</au><au>Leijten, Frans</au><au>Baayen, Johannes C</au><au>Aronica, Eleonora</au><au>Chassoux, Francine</au><au>Hamer, Hajo</au><au>Stefan, Hermann</au><au>Rössler, Karl</au><au>Thom, Maria</au><au>Walker, Matthew C</au><au>Sisodiya, Sanjay M</au><au>Duncan, John S</au><au>McEvoy, Andrew W</au><au>Pieper, Tom</au><au>Holthausen, Hans</au><au>Kudernatsch, Manfred</au><au>Meencke, H. Joachim</au><au>Kahane, Philippe</au><au>Schulze-Bonhage, Andreas</au><au>Zentner, Josef</au><au>Heiland, Dieter H</au><au>Urbach, Horst</au><au>Steinhoff, Bernhard J</au><au>Bast, Thomas</au><au>Tassi, Laura</au><au>Lo Russo, Giorgio</au><au>Özkara, Cigdem</au><au>Oz, Buge</au><au>Krsek, Pavel</au><au>Vogelgesang, Silke</au><au>Runge, Uwe</au><au>Lerche, Holger</au><au>Weber, Yvonne</au><au>Honavar, Mrinalini</au><au>Pimentel, José</au><au>Arzimanoglou, Alexis</au><au>Ulate-Campos, Adriana</au><au>Noachtar, Soheyl</au><au>Hartl, Elisabeth</au><au>Schijns, Olaf</au><au>Guerrini, Renzo</au><au>Barba, Carmen</au><au>Jacques, Thomas S</au><au>Cross, J. Helen</au><au>Feucht, Martha</au><au>Mühlebner, Angelika</au><au>Grunwald, Thomas</au><au>Trinka, Eugen</au><au>Winkler, Peter A</au><au>Gil-Nagel, Antonio</au><au>Toledano Delgado, Rafael</au><au>Mayer, Thomas</au><au>Lutz, Martin</au><au>Zountsas, Basilios</au><au>Garganis, Kyriakos</au><au>Rosenow, Felix</au><au>Hermsen, Anke</au><au>von Oertzen, Tim J</au><au>Diepgen, Thomas L</au><au>Avanzini, Giuliano</au><aucorp>EEBB Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2017-10-26</date><risdate>2017</risdate><volume>377</volume><issue>17</issue><spage>1648</spage><epage>1656</epage><pages>1648-1656</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Examination of approximately 10,000 specimens obtained during surgery for intractable seizures in children and adults resulted in 36 distinct diagnoses in seven categories; the most common diagnoses were hippocampal sclerosis, ganglioglioma, and focal cortical dysplasia.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>29069555</pmid><doi>10.1056/NEJMoa1703784</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2017-10, Vol.377 (17), p.1648-1656 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1956097909 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Age Factors Age of Onset Brain - pathology Brain Neoplasms - complications Brain Neoplasms - pathology Child Children Cortex Databases as Topic Drug resistance Dysplasia Epilepsy Epilepsy - etiology Epilepsy - pathology Epilepsy - surgery Europe Female Hippocampus Hippocampus - pathology Histopathology Humans Male Malformations of Cortical Development - complications Malformations of Cortical Development - pathology Neurology Neuropathology Neurosurgery NMR Nuclear magnetic resonance Patients Pediatrics Sclerosis Seizures Surgery Temporal lobe Temporal Lobe - pathology Tumors |
| title | Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery |
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