Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

Examination of approximately 10,000 specimens obtained during surgery for intractable seizures in children and adults resulted in 36 distinct diagnoses in seven categories; the most common diagnoses were hippocampal sclerosis, ganglioglioma, and focal cortical dysplasia.

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Veröffentlicht in:	The New England journal of medicine 2017-10, Vol.377 (17), p.1648-1656
Hauptverfasser:	Blumcke, Ingmar, Spreafico, Roberto, Haaker, Gerrit, Coras, Roland, Kobow, Katja, Bien, Christian G, Pfäfflin, Margarete, Elger, Christian, Widman, Guido, Schramm, Johannes, Becker, Albert, Braun, Kees P, Leijten, Frans, Baayen, Johannes C, Aronica, Eleonora, Chassoux, Francine, Hamer, Hajo, Stefan, Hermann, Rössler, Karl, Thom, Maria, Walker, Matthew C, Sisodiya, Sanjay M, Duncan, John S, McEvoy, Andrew W, Pieper, Tom, Holthausen, Hans, Kudernatsch, Manfred, Meencke, H. Joachim, Kahane, Philippe, Schulze-Bonhage, Andreas, Zentner, Josef, Heiland, Dieter H, Urbach, Horst, Steinhoff, Bernhard J, Bast, Thomas, Tassi, Laura, Lo Russo, Giorgio, Özkara, Cigdem, Oz, Buge, Krsek, Pavel, Vogelgesang, Silke, Runge, Uwe, Lerche, Holger, Weber, Yvonne, Honavar, Mrinalini, Pimentel, José, Arzimanoglou, Alexis, Ulate-Campos, Adriana, Noachtar, Soheyl, Hartl, Elisabeth, Schijns, Olaf, Guerrini, Renzo, Barba, Carmen, Jacques, Thomas S, Cross, J. Helen, Feucht, Martha, Mühlebner, Angelika, Grunwald, Thomas, Trinka, Eugen, Winkler, Peter A, Gil-Nagel, Antonio, Toledano Delgado, Rafael, Mayer, Thomas, Lutz, Martin, Zountsas, Basilios, Garganis, Kyriakos, Rosenow, Felix, Hermsen, Anke, von Oertzen, Tim J, Diepgen, Thomas L, Avanzini, Giuliano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Age of Onset Brain - pathology Brain Neoplasms - complications Brain Neoplasms - pathology Child Children Cortex Databases as Topic Drug resistance Dysplasia Epilepsy Epilepsy - etiology Epilepsy - pathology Epilepsy - surgery Europe Female Hippocampus Hippocampus - pathology Histopathology Humans Male Malformations of Cortical Development - complications Malformations of Cortical Development - pathology Neurology Neuropathology Neurosurgery NMR Nuclear magnetic resonance Patients Pediatrics Sclerosis Seizures Surgery Temporal lobe Temporal Lobe - pathology Tumors
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Beschreibung
Zusammenfassung:	Examination of approximately 10,000 specimens obtained during surgery for intractable seizures in children and adults resulted in 36 distinct diagnoses in seven categories; the most common diagnoses were hippocampal sclerosis, ganglioglioma, and focal cortical dysplasia.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1703784