Enantiospecific total synthesis of the squalene synthase inhibitors (–)-CJ-13,982 and its enantiomer from a common intermediate

The total syntheses of both the natural and unnatural enantiomers of the alkyl citrate natural product CJ-13,982 ( 1 ) from the common d -ribose-derived acid 6 are described.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2018-02, Vol.71 (2), p.234-239
Hauptverfasser:	Sturgess, Dayna, Chen, Zongjia, White, Jonathan M, Rizzacasa, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	639/638/403/935 639/638/403/977 Acids Alcohol Antibiotics Bacteriology Biological Products Biomedical and Life Sciences Bioorganic Chemistry Chemistry Chromatography Citrates - chemistry D-Ribose Enantiomers Enzyme Inhibitors - chemical synthesis Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors Indicators and Reagents Life Sciences Medicinal Chemistry Microbiology Molecular Conformation Natural products Organic Chemistry original-article Palmitic Acids - chemical synthesis Ribose Squalene Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The total syntheses of both the natural and unnatural enantiomers of the alkyl citrate natural product CJ-13,982 ( 1 ) from the common d -ribose-derived acid 6 are described.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2017.127