Immune reconstitution inflammatory syndrome in the first year after HAART : influence on long-term clinical outcome

Immune reconstitution inflammatory syndrome in the first year after HAART : influence on long-term clinical outcome

Little is known about the effect of immune reconstitution inflammatory syndrome (IRIS) on the long-term clinical outcome. Of 52 opportunistic infections (OI) occurring within one year after the start of HAART in 387 HIV patients, 33 (63%) were classified as having IRIS. The patients with IRIS showed...

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Veröffentlicht in:AIDS (London) 2006-11, Vol.20 (18), p.2390-2392
Hauptverfasser: WAN BEOM PARK, PYOENG GYUN CHOE, JAE HYUN JO, KIM, Sung-Han, JI HWAN BANG, HONG BIN KIM, NAM JOONG KIM, OH, Myoung-Don, KANG WON CHOE
Format: Artikel
Sprache:eng
Schlagworte:
Adult
AIDS-Related Opportunistic Infections - immunology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active - adverse effects
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Female
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Immune System Diseases - immunology
Infectious diseases
Kaplan-Meier Estimate
Male
Medical sciences
Pharmacology. Drug treatments
Retrospective Studies
Syndrome
Treatment Outcome
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Zusammenfassung:Little is known about the effect of immune reconstitution inflammatory syndrome (IRIS) on the long-term clinical outcome. Of 52 opportunistic infections (OI) occurring within one year after the start of HAART in 387 HIV patients, 33 (63%) were classified as having IRIS. The patients with IRIS showed no significant difference in the AIDS event-free survival curve compared with the matched control group without OI and in contrast to non-IRIS OI.
ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0b013e328010f201