Do admission glucose levels aid in predicting mortality associated with community-acquired pneumonia?

Diabetes mellitus increases the risk of and mortality associated with community-acquired pneumonia (CAP) [1]. Hyperglycaemia negatively impacts both the innate and adaptive immune response, which could lead to decreased bacterial clearance and increased mortality from infection [2]. This can be exte...

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Veröffentlicht in:The European respiratory journal 2017-10, Vol.50 (4), p.1700307-1700307
Hauptverfasser: Postma, Douwe F, van Werkhoven, Cornelis H, Troeman, Darren P R, Sankatsing, Sanjay U C, Oosterheert, Jan Jelrik, Bonten, Marc J M
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Sprache:eng
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Zusammenfassung:Diabetes mellitus increases the risk of and mortality associated with community-acquired pneumonia (CAP) [1]. Hyperglycaemia negatively impacts both the innate and adaptive immune response, which could lead to decreased bacterial clearance and increased mortality from infection [2]. This can be extended to non-diabetic patients as well: hyperglycaemia on admission is an independent risk factor for higher complication rates, longer length of stay, and higher mortality in diabetics and non-diabetics with CAP [3–6]. Hypoglycaemia on admission has also been associated with an independent increased risk of mortality in patients with CAP [7, 8]. Currently, two severity scoring systems are widely used for predicting CAP mortality: the pneumonia severity index (PSI) and CURB-65 score (confusion, urea >7 mmol·L−1, respiratory rate ≥30 breaths·min−1, blood pressure
ISSN:0903-1936
1399-3003
DOI:10.1183/13993003.00307-2017