Key role of clathrin-mediated endocytosis in synaptic vesicle recycling

Key role of clathrin-mediated endocytosis in synaptic vesicle recycling

Using novel fluorescent markers, virus-induced modulation of amphiphysin 1 expression, and electron microscopy, we demonstrated that clathrin-mediated endocytosis is the main mechanism of synaptic vesicle retrieval; a hypothesis on the role of a fast "kiss-and-run" mechanism has not been s...

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Veröffentlicht in:Neurophysiology (New York) 2007-07, Vol.39 (4-5), p.339-340
Hauptverfasser: Tsytsyura, Y, Glyvuk, N, Krikunova, M, Jung, N, Haucke, V, Klingauf, J
Format: Artikel
Sprache:eng
Schlagworte:
Anatomy & physiology
Neurons
Neurosciences
Neurotransmitters
Proteins
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Zusammenfassung:Using novel fluorescent markers, virus-induced modulation of amphiphysin 1 expression, and electron microscopy, we demonstrated that clathrin-mediated endocytosis is the main mechanism of synaptic vesicle retrieval; a hypothesis on the role of a fast "kiss-and-run" mechanism has not been supported. [PUBLICATION ABSTRACT]
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-007-0050-5