GM-CSF Gene-Modifed Cancer Cell Immunotherapies: Of Mice and Men

GVAX cancer immunotherapies are composed of whole tumor cells genetically modified to secrete the immune stimulatory cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), and then irradiated to prevent further cell division. Both autologous (patient specific) and allogeneic (non-patie...

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Veröffentlicht in:International reviews of immunology 2006-09, Vol.25 (5-6), p.321-352
Hauptverfasser: Hege, Kristen M., Jooss, Karin, Pardoll, Drew
Format: Artikel
Sprache:eng
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Zusammenfassung:GVAX cancer immunotherapies are composed of whole tumor cells genetically modified to secrete the immune stimulatory cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), and then irradiated to prevent further cell division. Both autologous (patient specific) and allogeneic (non-patient specific) GVAX platforms have been evaluated either as single agents or in combination with other immunomodulatory strategies. Many early-phase clinical trials have now been completed. Results have consistently demonstrated a favorable safety profile manifested primarily by injection site reactions and flu-like symptoms. Consistent evidence of immune activation and clinical activity, including radiologic tumor regressions, has been seen across multiple cancer indications in both early- and late-stage disease. Phase 3 trials evaluating an allogeneic GVAX immunotherapy product in prostate cancer are under way.
ISSN:0883-0185
1563-5244
DOI:10.1080/08830180600992498