Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition

Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition

Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the macrolactone 3 was constructed through a chemo- and regioselective intramolecular nitrile oxide cycloaddition of diene 4.

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Veröffentlicht in:Organic letters 2017-11, Vol.19 (21), p.6004-6007
Hauptverfasser: Choe, Hyeonjeong, Cho, Hyukjoon, Ko, Hyun-Jeong, Lee, Jongkook
Format: Artikel
Sprache:eng
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Zusammenfassung:Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the macrolactone 3 was constructed through a chemo- and regioselective intramolecular nitrile oxide cycloaddition of diene 4.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03054