Value of the HLA-B5701 Allele to Predict Abacavir Hypersensitivity in Spaniards
The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA...
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| Veröffentlicht in: | AIDS research and human retroviruses 2007-11, Vol.23 (11), p.1374-1376 |
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| container_title | AIDS research and human retroviruses |
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| creator | RODRIGUEZ-NOVOA, Sonia GARCIA-GASCO, Pilar BLANCO, Francisco GONZALEZ-PARDO, Gema CASTELLARES, Carol MORENO, Victoria JIMENEZ-NACHER, Inmaculada GONZALEZ-LAHOZ, Juan SORIANO, Avincent |
| description | The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spaniards infected with HIV who received ABC treatment. The presence of HLA-B5701 had strong positive and negative predictive values for ABC HSR, 92% and 63%, respectively. |
| doi_str_mv | 10.1089/aid.2006.0244 |
| format | Article |
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The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spaniards infected with HIV who received ABC treatment. The presence of HLA-B5701 had strong positive and negative predictive values for ABC HSR, 92% and 63%, respectively.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2006.0244</identifier><identifier>PMID: 18184080</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Abacavir ; Allergic reaction ; Allergy ; Anti-HIV Agents - adverse effects ; Biological and medical sciences ; Demographic aspects ; Dideoxynucleosides - adverse effects ; Dosage and administration ; Drug Hypersensitivity - genetics ; Drug therapy ; Fundamental and applied biological sciences. 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The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spaniards infected with HIV who received ABC treatment. The presence of HLA-B5701 had strong positive and negative predictive values for ABC HSR, 92% and 63%, respectively.</description><subject>Abacavir</subject><subject>Allergic reaction</subject><subject>Allergy</subject><subject>Anti-HIV Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Demographic aspects</subject><subject>Dideoxynucleosides - adverse effects</subject><subject>Dosage and administration</subject><subject>Drug Hypersensitivity - genetics</subject><subject>Drug therapy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Testing</subject><subject>HLA-B Antigens - genetics</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Predictive Value of Tests</subject><subject>Retrovirus</subject><subject>Spain</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0M-LEzEYxvEgiltXj14lIHqb-r7JpJMcx0WtUFjBH9fwTuYdjaQzNZku9L93Sgt7ei8f3ge-QrxGWCNY94Fiv1YAmzWoun4iVug0VrYG81SswFpXKaXcjXhRyl8AcEqZ5-IGLS7Ewkrc_6J0ZDkNcv7Dcrtrq4-mAZRtSpxYzpP8lrmPYZZtR4EeYpbb04Fz4bHEOT7E-STjKL8faIyU-_JSPBsoFX51vbfi5-dPP-621e7-y9e7dlcFbWGump5ZUeixY6oboxqw7FihcxywQ6wDK9AanB5cMNooYuw2vRkCkWmo1rfi_eXvIU__jlxmv48lcEo08nQsHp1RztZmgW8v8Dcl9nEcpjlTOGPfosNN3aDCRVUXFfJUSubBH3LcUz55BH_u7JfO_tzZnzsv_s11_tjtuX_U17ALeHcFVAKlIdMYYnl0zjrtmo3-DwrIgys</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>RODRIGUEZ-NOVOA, Sonia</creator><creator>GARCIA-GASCO, Pilar</creator><creator>BLANCO, Francisco</creator><creator>GONZALEZ-PARDO, Gema</creator><creator>CASTELLARES, Carol</creator><creator>MORENO, Victoria</creator><creator>JIMENEZ-NACHER, Inmaculada</creator><creator>GONZALEZ-LAHOZ, Juan</creator><creator>SORIANO, Avincent</creator><general>Liebert</general><general>Mary Ann Liebert, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20071101</creationdate><title>Value of the HLA-B5701 Allele to Predict Abacavir Hypersensitivity in Spaniards</title><author>RODRIGUEZ-NOVOA, Sonia ; GARCIA-GASCO, Pilar ; BLANCO, Francisco ; GONZALEZ-PARDO, Gema ; CASTELLARES, Carol ; MORENO, Victoria ; JIMENEZ-NACHER, Inmaculada ; GONZALEZ-LAHOZ, Juan ; SORIANO, Avincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-7dee2acd1bea4752708e9e2199ec1b114ce2033093f9c5352ae1b6d5fcaa57a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Abacavir</topic><topic>Allergic reaction</topic><topic>Allergy</topic><topic>Anti-HIV Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Demographic aspects</topic><topic>Dideoxynucleosides - adverse effects</topic><topic>Dosage and administration</topic><topic>Drug Hypersensitivity - genetics</topic><topic>Drug therapy</topic><topic>Fundamental and applied biological sciences. 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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Abacavir Allergic reaction Allergy Anti-HIV Agents - adverse effects Biological and medical sciences Demographic aspects Dideoxynucleosides - adverse effects Dosage and administration Drug Hypersensitivity - genetics Drug therapy Fundamental and applied biological sciences. Psychology Genetic Testing HLA-B Antigens - genetics Human immunodeficiency virus Human viral diseases Humans Infectious diseases Medical sciences Microbiology Miscellaneous Predictive Value of Tests Retrovirus Spain Viral diseases Virology |
| title | Value of the HLA-B5701 Allele to Predict Abacavir Hypersensitivity in Spaniards |
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