Value of the HLA-B5701 Allele to Predict Abacavir Hypersensitivity in Spaniards

The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA...

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Veröffentlicht in:	AIDS research and human retroviruses 2007-11, Vol.23 (11), p.1374-1376
Hauptverfasser:	RODRIGUEZ-NOVOA, Sonia, GARCIA-GASCO, Pilar, BLANCO, Francisco, GONZALEZ-PARDO, Gema, CASTELLARES, Carol, MORENO, Victoria, JIMENEZ-NACHER, Inmaculada, GONZALEZ-LAHOZ, Juan, SORIANO, Avincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Abacavir Allergic reaction Allergy Anti-HIV Agents - adverse effects Biological and medical sciences Demographic aspects Dideoxynucleosides - adverse effects Dosage and administration Drug Hypersensitivity - genetics Drug therapy Fundamental and applied biological sciences. Psychology Genetic Testing HLA-B Antigens - genetics Human immunodeficiency virus Human viral diseases Humans Infectious diseases Medical sciences Microbiology Miscellaneous Predictive Value of Tests Retrovirus Spain Viral diseases Virology
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Zusammenfassung:	The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B5701 in 53 Spaniards infected with HIV who received ABC treatment. The presence of HLA-B5701 had strong positive and negative predictive values for ABC HSR, 92% and 63%, respectively.
ISSN:	0889-2229 1931-8405
DOI:	10.1089/aid.2006.0244