Age-Related Changes of Heart Rate Variability at Various Insulin Sensitivity and Telomere Length

To study relationship between age-associated changes of heart rate variability (HRV), telomere length (TL), and lowering of insulin sensitivity (IS). We included in this study 229 individuals aged 23‒91 years without clinical manifestations of cardiovascular and other somatic diseases. In all participants, we analyzed HRV parameters obtained at 24-hour ECG monitoring (24-h ECG) and 5 minutes ECG recordings in the supine and standing positions. Leukocyte TL was estimated on genomic DNA using real time polymerase chain reaction. Insulin sensitivity was characterized by calculation of НОМА-IR and Gutt's insulin sensitivity index (ISI). Elderly people with short telomeres (.