Kit for instant super(99m)Tc labeling of the antimicrobial peptide ubiquicidin 29-41

The ubiquicidin 29-41 fragment (UBI) is a cationic antimicrobial peptide. The aim of this study was to develop an instant kit formulation for the preparation of super(99m)Tc-UBI 29-41 in high radiochemical yield and to evaluate its use as an infection imaging agent in humans. The components were selected to produce a direct super(99m)Tc labeling, presumably to the amine groups of Lys and Arg7. super(99m)Tc-UBI 29-41 obtained from the lyophilized kit showed radiochemical purity of >97% with an average target/non-target ratio of 2.3 plus or minus 0.6 in positive infection sites at 2 hours. Kits were stable at 4 degree C for over 6 months.