Modulatory role of lipoic acid on adriamycin-induced testicular injury

The present study investigated the protective efficacy of dl-α-lipoic acid (LA) on adriamycin (ADR)-induced oxidative damage in rat testis. Adult male albino rats of Wistar strain were administered ADR (1 mg/kg body weight, i.v.), once a week for 10 weeks. ADR injected rats showed increased oxidativ...

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Veröffentlicht in:	Chemico-biological interactions 2006-03, Vol.160 (2), p.108-114
Hauptverfasser:	Prahalathan, Chidambaram, Selvakumar, Elangovan, Varalakshmi, Palaninathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adriamycin Animals Antibiotics, Antineoplastic - toxicity Antioxidants - pharmacology Cellular thiols Doxorubicin - toxicity Drug Antagonism Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Lipoic acid Male Microscopy, Electron, Transmission Oxidative stress Oxidative Stress - drug effects PHGPx Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Spermatocytes - drug effects Spermatocytes - ultrastructure TEM Testicular Diseases - metabolism Testicular Diseases - pathology Testicular Diseases - prevention & control Testicular toxicity Testis - drug effects Testis - pathology Thioctic Acid - pharmacology
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Zusammenfassung:	The present study investigated the protective efficacy of dl-α-lipoic acid (LA) on adriamycin (ADR)-induced oxidative damage in rat testis. Adult male albino rats of Wistar strain were administered ADR (1 mg/kg body weight, i.v.), once a week for 10 weeks. ADR injected rats showed increased oxidative stress with a concomitant decrease in cellular thiols. The mRNA level for phospholipid hydroperoxide glutathione peroxidase (PHGPx) was also significantly decreased by ADR administration. Transmission electron microscopic (TEM) observations of testicular germ cells revealed abnormal ultrastructural changes in ADR treated rats. Treatment with lipoic acid (35 mg/kg body weight, i.p.) 1 day prior to ADR administration, effectively reverted these abnormal changes towards normalcy. These findings indicate a cytoprotective role of LA in this experimental model of testicular toxicity.
ISSN:	0009-2797 1872-7786
DOI:	10.1016/j.cbi.2005.12.007