Biotransformation of Physalin H and Leishmanicidal Activity of Its Transformed Products

Biotransformation of Physalin H and Leishmanicidal Activity of Its Transformed Products

The transformation of physalin H (1) with Rhizopus stolonifer and Cunninghamella elegans has afforded two new physalins, 6,7-dehydrophysalin H (2) and 6-deoxyphysalin H (3), along with a known isophysalin B (4). Their structures were elucidated by spectroscopic analysis. All of these compounds have...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2006, Vol.54(7), pp.927-930
Hauptverfasser: Choudhary, Muhammad Iqbal, Yousuf, Sammer, Samreen, Shah, Syed Adnan Ali, Ahmed, Shakil, Atta-ur-Rahman
Format: Artikel
Sprache:eng
Schlagworte:
Animals
antileishmanial
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Biotransformation
Cunninghamella - metabolism
Cunninghamella elegans
Inhibitory Concentration 50
Lactones - metabolism
Lactones - pharmacology
Leishmania major - drug effects
microbial transformation
Molecular Structure
Parasitic Sensitivity Tests
physalin
Rhizopus - metabolism
Rhizopus stolonifer
Secosteroids
Spectrophotometry, Ultraviolet
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The transformation of physalin H (1) with Rhizopus stolonifer and Cunninghamella elegans has afforded two new physalins, 6,7-dehydrophysalin H (2) and 6-deoxyphysalin H (3), along with a known isophysalin B (4). Their structures were elucidated by spectroscopic analysis. All of these compounds have shown potent leishmanicidal activity with IC50 values in the range of 6.03—13.80 μM.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.54.927